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Issue 130, Volume 20

 

 

May 16, 2019 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: INKA1 promotes leukemia stem cell latency. See the article by Kaufmann et al.

Active surveillance for nodular lymphocyte-predominant Hodgkin lymphoma
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is frequently treated aggressively. In a Plenary Paper, Borchmann et al demonstrate in a retrospective study of 167 patients that active surveillance yields excellent outcomes equivalent to those of early therapy.


Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells
Karschnia and colleagues report on the diagnostic features and management of chimeric antigen receptor (CAR) T cell–related neurotoxicity, and they discuss biomarkers that predict outcomes.


HAP1 loss confers L-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway
In this month’s CME article, Lee et al demonstrate that loss of huntingtin-associated protein 1 (HAP1) expression induces resistance to L-asparaginase in acute lymphoblastic leukemia (ALL), identifying a potential novel therapeutic pathway to restore sensitivity in L-asparaginase–resistant patients.


Comprehensive clinical-molecular transplant scoring system for myelofibrosis undergoing stem cell transplantation
Gagelmann et al integrate clinical, molecular, and transplant-specific features of 361 patients with myelofibrosis to develop a scoring system predicting outcomes of hematopoietic stem cell transplantation (HSCT) and identifying patients most likely to benefit from early HSCT.


A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency
Kaufmann et al demonstrate that INKA1 modulates leukemia stem cell (LSC) latency. Overexpression of INKA1 preserves LSC latency and leads to expansion of quiescent CD34+ stem cells.


Review Series: Human Neutrophils
Neutrophils are critical to innate immunity and serve as the major phagocytic defense against invading organisms. This Review Series focuses on novel insights into the “secret lives” of neutrophils, which have critical roles in modulating hematopoiesis and the hematopoietic niche, influencing inflammatory responses, regulating the tumor microenvironment, and promoting thrombosis.


The articles in this review series include the following:


View this week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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