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Blood's First Edition Papers: Last updated December 1, 2008 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 1 December 2008 Raquel Malumbres, Kristopher A. Sarosiek, Elena Cubedo, Jose W Ruiz, Xiaoyu Jiang, Randy D Gascoyne, Robert Tibshirani, and Izidore S Lossos Differentiation-stage-specific expression of microRNAs in B-lymphocytes and diffuse large B-cell lymphomas Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-10-184077 [Abstract] [PDF]   Joji Nakayama, Mutsumi Yamamoto, Katsuhiko Hayashi, Hitoshi Satoh, Kenji Bundo, Masato Kubo, Ryo Goitsuka, Michael A Farrar, and Daisuke Kitamura BLNK suppresses pre-B cell leukemogenesis through inhibition of JAK3 Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-07-166355 [Abstract] [PDF]   Samira Lakhal, Nick P Talbot, Alexi Crosby, Chantal Stoepker, Alain R M Townsend, Peter A Robbins, Christopher W Pugh, Peter J Ratcliffe, and David R Mole Regulation of growth differentiation factor 15 expression by intracellular iron Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-07-170431 [Abstract] [PDF]   Franz X Schaub, Roland Jager, Renate Looser, Hui Hao-Shen, Sylvie Hermouet, Francois Girodon, Andre Tichelli, Heinz Gisslinger, Robert Kralovics, and Radek C Skoda Clonal analysis of deletions on chromosome 20q and JAK2-V617F in MPD suggests that del20q acts independently and is not one of the pre-disposing mutations for JAK2-V617F Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-07-167056 [Abstract] [PDF]   Paula G. Fraenkel, Yann Gibert, Jason L Holzheimer, Victoria J Lattanzi, Sarah F Burnett, Kimberly A Dooley, Rebecca A Wingert, and Leonard I Zon Transferrin-a modulates hepcidin expression in zebrafish embryos Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-06-165340 [Abstract] [PDF]   Michelle D Gardner, Chan K. N. K. Chion, Rens de Groot, Anuja Shah, James T.B. Crawley, and David A. Lane A functional calcium binding site in the metalloprotease domain of ADAMTS13 Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-03-144683 [Abstract] [PDF]   Lian-Qun Qiu, Peter Cresswell, and Keh-Chuang Chin Viperin is required for optimal Th2 responses and T cell receptor-mediated activation of NF-B and AP-1 Blood First Edition Paper, prepublished online December 1, 2008; DOI 10.1182/blood-2008-07-171942 [Abstract] [PDF]   25 November 2008 Anne R Kinderlerer, Isabel Pombo Gregoire, Shahir S Hamdulay, Faisal Ali, Rivka Steinberg, Gabriela Silva, Nadira Ali, Bufei Wang, Dorian O Haskard, Miguel P Soares, and Justin C Mason Heme oxygenase-1 expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor. A role for increased bilirubin and ferritin Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-04-152934 [Abstract] [PDF]   Keishi Otsu, Shonit Das, Sandra D. Houser, Sadiqa K Quadri, Sunita Bhattacharya, and Jahar Bhattacharya Concentration dependent inhibition of angiogenesis by mesenchymal stem cells Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-09-176198 [Abstract] [PDF]   Giannoula Lakka Klement, Tai-Tung Yip, Flavia Cassiola, Lena Kikuchi, David Cervi, Vladimir Podust, Joseph E Italiano, Erin Wheatley, Abdo Abou-Slaybi, Elise Bender, Nava Almog, Mark Kieran, and Judah Folkman Platelets actively sequester angiogenesis regulators Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-06-159541 [Abstract] [PDF]   Suyong Choi, Sin-Ae Lee, Tae Kyoung Kwak, Hyeon Jung Kim, Mi Ji Lee, Sang-Kyu Ye, Sung-Hoon Kim, Semi Kim, and Jung Weon Lee Cooperation between integrin 5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-05-160671 [Abstract] [PDF]   Ming Yan, Eun-Young Ahn, Scott W. Hiebert, and Dong-Er Zhang RUNX1/AML1 DNA binding domain and ETO/MTG8 NHR2 dimerization domain are critical to AML1-ETO9a leukemogenesis Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-04-153742 [Abstract] [PDF]   Adili Reheman, Hong Yang, Guangheng Zhu, Wuxun Jin, Feng He, Christopher M. Spring, Xufang Bai, Peter L. Gross, John Freedman, and Heyu Ni Plasma fibronectin depletion enhances platelet aggregation and thrombus formation in mice lacking fibrinogen and von Willebrand factor Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2008-04-148361 [Abstract] [PDF]   Melanie Fakler, Sandra Loder, Meike Vogler, Katja Schneider, Irmela Jeremias, Klaus-Michael Debatin, and Simone Fulda Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance Blood First Edition Paper, prepublished online November 25, 2008; DOI 10.1182/blood-2007-09-114314 [Abstract] [PDF]   24 November 2008 Antonis Dagklis, Claudia Fazi, Cinzia Sala, Valeria Cantarelli, Cristina Scielzo, Roberto Massacane, Daniela Toniolo, Federico Caligaris-Cappio, Kostas Stamatopoulos, and Paolo Ghia The immunoglobulin gene repertoire of low-count CLL-like MBL is different from CLL: diagnostic implications for clinical monitoring Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-09-176933 [Abstract] [PDF]   David Dayde, David Ternant, Marc Ohresser, Stephanie Lerondel, Sabrina Pesnel, Herve Watier, Alain Le Pape, Pierre Bardos, Gilles Paintaud, and Guillaume Cartron Tumor burden influences exposure and response to rituximab: pharmacokinetic - pharmacodynamic modelling using a syngeneic bioluminescent murine model expressing human CD20 Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-08-175125 [Abstract] [PDF]   Julia E Maxson, Caroline A Enns, and An-Sheng Zhang Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-08-174565 [Abstract] [PDF]   Wing-yan Au, Dennis D. Weisenburger, Tanin Intragumtornchai, Shigeo Nakamura, Won-Seog Kim, Ivy Sng, Julie Vose, James O. Armitage, and Raymond Liang Clinical differences between nasal and extranasal NK/T-cell lymphoma: a study of 136 cases from the International Peripheral T-cell Lymphoma Project Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-10-185256 [Abstract] [PDF]   Nathalie A Johnson, Merrill Boyle, Ali Bashashati, Stephen Leach, Angela Brooks-Wilson, Laurie H Sehn, Mukesh Chhanabhai, Ryan R Brinkman, Joseph M. Connors, Andrew P Weng, and Randy D Gascoyne Diffuse large B cell lymphoma: reduced CD20 expression is associated with an inferior survival Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-09-177469 [Abstract] [PDF]   Keith W Pratz, Jorge Cortes, Gail J. Roboz, Niranjan Rao, Omotayo Arowojolu, Adam Stine, Yukimasa Shiotsu, Aiko Shudo, Shiro Akinaga, Donald Small, Judith E Karp, and Mark Levis A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-09-177030 [Abstract] [PDF]   D. Kika Veljkovic, Georges E. Rivard, Maria Diamandis, Jessica Blavignac, Elisabeth M. Cramer-Borde, and Catherine P. M. Hayward Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-08-172338 [Abstract] [PDF]   Sarah J Horton, Vanessa Walf-Vorderwulbecke, Steve J Chatters, Neil J Sebire, Jasper de Boer, and Owen Williams Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-07-170480 [Abstract] [PDF] [Supplemental Figures]   Saskia Kuipers, Suzanne C Cannegieter, Carine J.M. Doggen, and Frits R. Rosendaal The effect of elevated levels of coagulation factors on the risk of venous thrombosis in long distance travellers Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-06-160135 [Abstract] [PDF]   Petra Krause, Markus Bruckner, Christina Uermosi, Eva Singer, Marcus Groettrup, and Daniel F. Legler Prostaglandin E2 enhances T cell proliferation by inducing the co-stimulatory molecules OX40L, CD70 and 4-1BBL on dendritic cells Blood First Edition Paper, prepublished online November 24, 2008; DOI 10.1182/blood-2008-05-157123 [Abstract] [PDF]   20 November 2008 Nancy S. Longo, Patricia L. Lugar, Sule Yavuz, Wen Zhang, Peter H. L. Krijger, Daniel E. Russ, Dereje D. Jima, Sandeep S. Dave, Amrie C. Grammer, and Peter E. Lipsky Analysis of somatic hypermutation in X-HIgM syndrome reveals specific deficiencies in mutational targeting Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-10-183632 [Abstract] [PDF]   Susan Yuditskaya, Ashaunta Tumblin, Gerard T. Hoehn, Guanghui Wang, Steven K. Drake, Xiuli Xu, Saixia Ying, Amy H. Chi, Alan T. Remaley, Rong-Fong Shen, Peter J. Munson, Anthony F. Suffredini, and Gregory J. Kato Proteomic identification of altered apolipoprotein patterns in pulmonary hypertension and vasculopathy of sickle cell disease Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-03-142604 [Abstract] [PDF] [Supplemental Methods and Figures]   Ying Jiang, Andrew Dunbar, Lukasz P. Gondek, Sanjay Mohan, Manjot Rataul, Christine O'Keefe, Mikkael Sekeres, Yogen Saunthararajah, and Jaroslaw P. Maciejewski Aberrant DNA methylation is a dominant mechanism in MDS progression to AML Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-06-163246 [Abstract] [PDF]   Wei Zhang, Michael A Nardi, Zongdong Li, William Borkowsky, and Simon Karpatkin Role of molecular mimickry of hepatitis C-virus (HCV) protein with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-09-181073 [Abstract] [PDF]   Swapan K. Dasgupta, Hanan Abdel-Monem, Polly Niravath, Anhquyen Le, Ricardo V Bellera, Kimberly Langlois, Shigekazu Nagata, Rolando E. Rumbaut, and Perumal Thiagarajan Lactadherin and clearance of platelet-derived microvesicles Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-07-167148 [Abstract] [PDF]   Antonio Curti, Sara Trabanelli, Valentina Salvestrini, Michele Baccarani, and Roberto M. Lemoli The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: Focus on hematology Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-07-144485 [Abstract] [PDF]   Anna Shvets, Rabindranath Chakrabarti, Rosana Gonzalez-Quintial, Roberto Baccala, Argyrios N Theofilopoulos, and Gerald J Prud'homme Impaired negative regulation of homeostatically proliferating T cells Blood First Edition Paper, prepublished online November 20, 2008; DOI 10.1182/blood-2008-03-139964 [Abstract] [PDF]   19 November 2008 Asa Rangert Derolf, Sigurdur Yngvi Kristinsson, Therese M-L Andersson, Ola Landgren, Paul W Dickman, and Magnus Bjorkholm Improved patient survival for acute myeloid leukemia: A population-based study of 9,729 patients diagnosed in Sweden 1973-2005 Blood First Edition Paper, prepublished online November 19, 2008; DOI 10.1182/blood-2008-09-179341 [Abstract] [PDF]   Fouad Eddahri, Sebastien Denanglaire, Fabrice Bureau, Rosanne Spolski, Warren J Leonard, Oberdan Leo, and Fabienne Andris Interleukin-6 / STAT3 signalling regulates the ability of naive T cells to acquire B cell help capacities Blood First Edition Paper, prepublished online November 19, 2008; DOI 10.1182/blood-2008-04-154682 [Abstract] [PDF]   Enrique M. Ocio, Patricia Maiso, Xi Chen, Mercedes Garayoa, Stela Alvarez-Fernandez, Laura San-Segundo, David Vilanova, Lucia Lopez-Corral, Juan C. Montero, Teresa Hernandez-Iglesias, Enrique de Alava, Carlos Galmarini, Pablo Aviles, Carmen Cuevas, Jesus F. San-Miguel, and Atanasio Pandiella Zalypsis: A novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double strand breaks Blood First Edition Paper, prepublished online November 19, 2008; DOI 10.1182/blood-2008-09-177774 [Abstract] [PDF]   Robert de Jonge, Wim J.E. Tissing, Jan Hendrik Hooijberg, Gerrit Jansen, Gertjan J. L. Kaspers, Jan Lindemans, Godefridus J Peters, and Rob Pieters Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia Blood First Edition Paper, prepublished online November 19, 2008; DOI 10.1182/blood-2008-07-165928 [Abstract] [PDF]   Manuela Germeshausen, Karl Welte, and Matthias Ballmaier In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia Blood First Edition Paper, prepublished online November 19, 2008; DOI 10.1182/blood-2008-09-178087 [Abstract] [PDF]   18 November 2008 Pierre Bruhns, Bruno Iannascoli, Patrick England, David A Mancardi, Nadine Fernandez, Sylvie Jorieux, and Marc Daeron Specificity and affinity of human Fc receptors and their polymorphic variants for human IgG subclasses Blood First Edition Paper, prepublished online November 18, 2008; DOI 10.1182/blood-2008-09-179754 [Abstract] [PDF]   Constanca Figueiredo, Miriam Wittmann, Dong Wang, Ralf Dressel, Axel Seltsam, Rainer Blasczyk, and Britta Eiz-Vesper Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells Blood First Edition Paper, prepublished online November 18, 2008; DOI 10.1182/blood-2008-06-162727 [Abstract] [PDF]   Marc S. Raab, Iris Breitkreutz, Giovanni Tonon, Jing Zhang, Patrick J Hayden, Thu Nguyen, Johannes H Fruehauf, Boris K Lin, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C Anderson, and Klaus Podar Targeting PKC: A novel role for beta-catenin in ER stress and apoptotic signaling Blood First Edition Paper, prepublished online November 18, 2008; DOI 10.1182/blood-2008-05-157040 [Abstract] [PDF]   17 November 2008 Steven P. Treon, Andrew R Branagan, Leukothea Ioakimidis, Jacob D. Soumerai, Christopher J. Patterson, Barry Turnbull, Parveen Wasi, Christos Emmanouilides, Stanley R. Frankel, Andrew Lister, Pierre Morel, Jeffrey Matous, Stephanie A. Gregory, and Eva Kimby Long term outcomes to fludarabine and rituximab in Waldenstrom macroglobulinemia Blood First Edition Paper, prepublished online November 17, 2008; DOI 10.1182/blood-2008-09-177329 [Abstract] [PDF]   Marcello Rotta, Barry E Storer, Firoozeh Sahebi, Judith A. Shizuru, Benedetto Bruno, Thoralf Lange, Edward D. Agura, Peter A. McSweeney, Michael A Pulsipher, Parameswaran Hari, Richard T. Maziarz, Thomas R. Chauncey, Frederick R. Appelbaum, Mohamed L. Sorror, William Bensinger, Brenda M. Sandmaier, Rainer F. Storb, and David G. Maloney Long-term outcome of patients with multiple myeloma after autologous hematopoietic cell transplantation and nonmyeloablative allografting Blood First Edition Paper, prepublished online November 17, 2008; DOI 10.1182/blood-2008-07-170746 [Abstract] [PDF]   Xu Wang, Li Ye, Wei Hou, Yu Zhou, Yan-Jian Wang, David S. Metzger, and Wen-Zhe Ho Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection Blood First Edition Paper, prepublished online November 17, 2008; DOI 10.1182/blood-2008-09-175000 [Abstract] [PDF]   Charlotte Sadaka, Marie-Annick Marloie-Provost, Vassili Soumelis, and Philippe Benaroch Developmental regulation of MHC II expression and transport in human plasmacytoid-derived dendritic cells Blood First Edition Paper, prepublished online November 17, 2008; DOI 10.1182/blood-2008-10-178152 [Abstract] [PDF]   Tait D Shanafelt, Neil E. Kay, Greg Jenkins, Timothy G. Call, Clive S Zent, Diane F Jelinek, William G. Morice, Justin Boysen, Liam Zakko, Susan Schwager, Susan L Slager, and Curtis A. Hanson B-cell count and survival: Differentiating chronic lymphocytic leukemia (CLL) from monoclonal B-cell lymphocytosis (MBL) based on clinical outcome Blood First Edition Paper, prepublished online November 17, 2008; DOI 10.1182/blood-2008-09-176149 [Abstract] [PDF]   14 November 2008 Jan J. Cornelissen, Bronno van der Holt, Gregor E.G. Verhoef, Mars B. van 't Veer, Marinus H.J. van Oers, Harry C. Schouten, Gert Ossenkoppele, Pieter Sonneveld, Johan Maertens, Marinus van Marwijk Kooy, Martijn R. Schaafsma, Pierre W. Wijermans, Douwe H. Biesma, Shulamit Wittebol, Paul J. Voogt, Joke W. Baars, Pierre Zachee, Leo F Verdonck, Bob Lowenberg, and Adriaan W. Dekker Myeloablative allogeneic versus autologous stem cell transplantation in adult patients with acute lymphoblastic leukemia in first remission: a prospective sibling donor versus no-donor comparison Blood First Edition Paper, prepublished online November 14, 2008; DOI 10.1182/blood-2008-07-168625 [Abstract] [PDF]   Tamara Tripic, Wulan Deng, Yong Cheng, Ying Zhang, Christopher R Vakoc, Gregory D Gregory, Ross C Hardison, and Gerd A Blobel SCL and associated proteins distinguish active from repressive GATA transcription factor complexes Blood First Edition Paper, prepublished online November 14, 2008; DOI 10.1182/blood-2008-07-169417 [Abstract] [PDF]   Robert R Jenq, Christopher G King, Christine Volk, David Suh, Odette M Smith, Uttam Rao, Nury Yim, Amanda M. Holland, Sydney X. Lu, Johannes L Zakrzewski, Gabrielle L Goldberg, Adi Diab, Onder Alpdogan, Olaf Penack, Il-Kang Na, Lucy W Kappel, Jedd D Wolchok, Alan N Houghton, Miguel-Angel Perales, and Marcel R.M. van den Brink Keratinocyte growth factor enhances DNA plasmid tumor vaccine responses following murine allogeneic bone marrow transplantation Blood First Edition Paper, prepublished online November 14, 2008; DOI 10.1182/blood-2008-05-155697 [Abstract] [PDF]   Ludmila Jirmanova, Dandapantula N Sarma, Dragana Jankovic, Paul R Mittelstadt, and Jonathan D Ashwell Genetic disruption of p38 Tyr-323 phosphorylation prevents TCR-mediated p38 activation and impairs IFN- production Blood First Edition Paper, prepublished online November 14, 2008; DOI 10.1182/blood-2008-04-153304 [Abstract] [PDF]   13 November 2008 Cyndi Wong, Yong Liu, Jana Yip, Rochna Chand, Janet L Wee, Lisa Oates, Bernhard Nieswandt, Adili Reheman, Heyu Ni, Nicole Beauchemin, and Denise E Jackson CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo Blood First Edition Paper, prepublished online November 13, 2008; DOI 10.1182/blood-2008-06-165043 [Abstract] [PDF]   Patrick G Gallagher, Douglas G Nilson, Laurie A Steiner, Yelena D Maksimova, Jolinta Y Lin, and David M Bodine An insulator with barrier element activity promotes -spectrin gene expression in erythroid cells Blood First Edition Paper, prepublished online November 13, 2008; DOI 10.1182/blood-2008-06-164954 [Abstract] [PDF]   Rita I Azevedo, Maria Vieira D Soares, Joao T Barata, Rita Tendeiro, Ana Serra-Caetano, Rui M.M. Victorino, and Ana E. Sousa IL-7 sustains CD31 expression in human naive CD4+