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Volume 132, Issue 11

 

 

September 13, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Platelets are essential for lung development. See the article by Tsukiji et al.

RHM genotype matching for transfusion support in sickle cell disease
This article presents a unique approach to RH genotyping of red blood cells to improve matching of patients and donors and reduce Rh alloimmunization. The approach will also improve utilization of an African-American blood donor inventory and optimize transfusion support for patients with sickle cell disease.


Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction
The investigators report on the consequences of platelet-lymphatic interactions in the lung. They document that platelet activation and release of platelet transforming growth factor β have a marked effect on lung development.


AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation
The investigators explore the relation between lipid metabolism and thrombosis and identify the energy sensor AMP-activated protein kinase (AMPK) in platelets as a regulator of thrombus formation.


Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination
This work demonstrates the concept that vaccination may enhance the effectiveness of chimeric antigen receptor (CAR) T cells directed against peptide–major histocompatibility complex (MHC) complexes. The development of CAR T cells recognizing peptide-MHC complexes rather than native antigens may be of fundamental importance for future CAR T-cell therapy.


PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells
In a plenary paper, the authors provide evidence that mutations of the serine-threonine phosphatase gene PPM1D confer a selective growth advantage in the presence of ongoing DNA damage. They further demonstrate that pharmacological targeting of PPM1D can reverse this effect.


How I treat the young patient with multiple myeloma
The treatment landscape for multiple myeloma has been transformed by the introduction of an array of novel therapeutic agents. The authors discuss their line treatment approach for young adults with newly diagnosed myeloma.


Differentiation-based model of hematopoietic stem cell functions and lineage pathways
In this Perspective article, the authors highlight the latest advances in hematopoietic stem cell behavior in native-state hematopoiesis.


Oncogenic activation of the STAT3 pathway drives PD-L1 expression in natural killer/T-cell lymphoma
The authors report on the link between natural killer (NK)/T-cell lymphoma, STAT3 mutations, STAT3 activation, and expression of PD-L1, and they emphasize the importance of PD-L1 for the field of NK/T cell lymphomas.


A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation
This article describes a novel engineered factor VIII therapeutic compound for treatment of hemophilia with a markedly enhanced von Willebrand factor (VWF) affinity, increased half-life, and reduced immunogenicity.

View this week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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