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Volume 132, Issue 17

 

 

October 25, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: How I Treat Series: management of medical complications in SCD and thalassemia. See the articles in the series.

SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery
In a plenary paper, the Primary Immune Deficiency Treatment Consortium reports data that are predictive of outcome after hematopoietic stem cell transplantation for severe combined immunodeficiency (SCID).


Introduction to a How I Treat series on sickle cell disease and thalassemia
Survival of patients with sickle cell disease and thalassemia has significantly improved, putting patients at risk for new disease-related complications when they grow older. We present a series of How I Treat articles that highlight the unique diagnostic and therapeutic issues associated with patients with hemoglobinopathies who survive into adulthood.


The articles in this "How I Treat" series include the following:


DNA methylation age is associated with an altered hemostatic profile in a multiethnic meta-analysis
This work identifies a significant relationship between age-related alterations in DNA methylation and thrombotic risk in older individuals.


Human AML activates the aryl hydrocarbon receptor pathway to impair NK cell development and function
In this paper, the investigators report a mechanism by which the aryl hydrocarbon receptor allows acute myeloid leukemia (AML) cells to escape natural killer (NK) cell–mediated antitumor surveillance.


Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa
The authors leveraged a custom microscale system to demonstrate that endothelial cells communicate with neutrophils via interleukin-6 and granulocyte-macrophage colony-stimulating factor in the presence of live Pseudomonas aeruginosa to enhance neutrophil transmigration.


B-cell receptor–mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma
In these investigations, the authors identify a protein signature of PD-L1+ B-cell lymphoma cells that may be of critical value for therapeutic targeting of PD-L1/PD-1 interaction in diffuse large B-cell lymphoma.

View this week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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