Volume 130, Issue 16

Cover Figure: Heterogeneity of PIEZO1 mutations in hereditary xerocytosis. See the article by Glogowska et al.

WASHINGTON, October 19, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

KIT signaling is dispensable for human mast cell progenitor development
In a Plenary paper, Dahlin and colleagues demonstrate that while stem cell factor (SCF) and KIT signaling are required for the development of mature circulating mast cells, mast cell progenitors can proliferate, survive, and mature in the presence of interleukin-3 without SCF/KIT signaling.

Red blood cells in thrombosis
In this Spotlight Review, Byrnes and Wolberg discuss how quantitative and functional abnormalities in red cells can impact arterial and venous thrombosis.

Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study
Crump et al present a retrospective analysis of 636 patients with refractory diffuse large B-cell lymphoma pooling data from 2 prospective clinical trials and 2 observational cohorts, reporting an overall response rate of 25% and a median survival of only 6.3 months.

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets
High-grade lymphomas with a molecular Burkitt lymphoma (mBL) signature are aggressive and have a poor prognosis. Bouska et al present a detailed molecular and functional analysis of adult mBL, demonstrating a different mutational landscape from pediatric disease, a high rate of double-hit lymphoma, and B-cell receptor pathway activation.

Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia
Lafage-Pochitaloff and colleagues use karyotype, DNA index, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction to delineate cytogenetic subgroups of adult Ph-negative B-cell precursor acute lymphoblastic leukemia and define prognostically important abnormalities.

Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
Hereditary xerocytosis (HX) is a heterogeneous dominantly inherited red cell disorder associated with erythrocyte dehydration. It is caused by mutations in PIEZO1, which encodes a pore-forming membrane channel. Glogowska et al perform a comprehensive analysis of the range of PIEZO1 mutations in HX and their cognate transport abnormalities that lead to cellular dehydration.


This week's complete table of contents

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