Volume 132, Issue 19



November 8, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: New mechanism of BCL6 regulation via PRMT5, relevant for lymphoma therapeutics. See the article by Lu et al.

Five-year follow-up of lenalidomide plus rituximab as initial treatment of mantle cell lymphoma
The authors report on the 5-year follow-up of a multicenter phase 2 study of patients with previously untreated mantle cell lymphoma who received the nonchemotherapy combination regimen of rituximab and lenalidomide for induction and maintenance therapy.

Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress
By comparing wild-type and erythroid-specific ferroportin knockout mice, the investigators estimate the contribution of iron efflux from erythroblasts and erythrocytes to total iron turnover.

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival
The investigators identify a novel mechanism of BCL6 regulation via PRMT5 with therapeutic implications potentially important for mature lymphoid malignancies.

Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
This study identifies novel immune function–related loci associated with significant susceptibility to Hodgkin lymphoma.

A mutation of the human EPHB2 gene leads to a major platelet functional defect
The authors used advanced genomic sequencing and functional analysis to identify a novel role for ephrin transmembrane receptor B2 (EPHB2) in causing a major platelet defect.

Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations
This study reveals that the A allele frequency of the F2RL3 rs773902 A/G dimorphism, associated with increased platelet reactivity, is significantly lower in Somalians than what was previously demonstrated for black persons in the United States, underscoring the importance of genetics and geographic ancestry for determination of disease risk.

Testing and monitoring direct oral anticoagulants
In this Perspective, the author discusses the reasons for testing levels of direct oral anticoagulants, including the need for dose adjustment and the importance of measuring levels in the setting of hemorrhage and other special situations.

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