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Volume 130, Issue 18

Cover Figure: HSCs are a source of relapse after CD19-directed therapy for Philadelphia chromosome–positive ALL. See the article by Nagel et al.

WASHINGTON, November 2, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Safety and persistence of WT1-specific T-cell receptor gene–transduced lymphocytes in patients with AML and MDS
WT1 is highly expressed in AML and MDS. Tawara and colleagues report the first in-human trial administering T lymphocytes transduced with a WT1-specific T-cell receptor in refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), demonstrating safety and persistence of the targeted cells.

Uncovering the mystery of opposite circadian rhythms between mouse and human leukocytes in humanized mice
Circulating leukocytes demonstrate circadian oscillation that manifests opposite rhythms in mice and humans. Zhao et al have created humanized mice that recapitulate this opposite rhythm and shed light on the molecular mechanism of this clock network.

Hematopoietic stem cell involvement in BCR-ABL1–positive ALL as a potential mechanism of resistance to blinatumomab therapy
Targeting CD19 with the bispecific T-cell engager blinatumomab is an effective therapy for resistant B-cell acute lymphoblastic leukemia (ALL); however, some patients relapse with CD19-negative leukemia. Nagel and colleagues demonstrate that this may reflect selection of preexisting CD19-negative malignant progenitors residing in the stem cell compartment.

Emerging mechanisms of long noncoding RNA function during normal and malignant hematopoiesis
Alvarez-Dominguez and Lodish review the current understanding of the role of long noncoding RNAs (lncRNAs) in modulating gene expression and normal cellular development and how disruption of lncRNA function contributes to malignant transformation.

How I treat patients with HIV-related hematological malignancies using hematopoietic cell transplantation
Alvarnas and colleagues discuss their approach to autologous and allogeneic transplantation in HIV-positive patients with hematologic malignancies.

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth
Vps34 is a phosphoinositide 3-kinase (PI3K) expressed in megakaryocytes and platelets. Valet et al report the phenotype of a Vps34-null mouse which has microthrombocytopenia and abnormal platelet granules. They demonstrate that, in addition to its influence on platelet production, Vps34 has a previously unexpected role in platelet activation and arterial thrombosis.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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