Volume 130, Issue 20

Cover Figure: CLEC 2 increases thrombus stability independently of classical receptor signaling. See the article by Haining et al.

WASHINGTON, November 16, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis
In a plenary paper, Zhang et al describe a pig model of congenital hypothyroidism with the characteristic features of impaired erythropoiesis and lymphopoiesis. They demonstrate that the KLF9 gene is regulated by thyroid hormone and that its downregulation is responsible for the hematopoietic defects in severe hypothyroidism.

Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma
Moskowitz and colleagues present new data that further confirm the value of quantitative positron emission tomography (PET) analysis as a guide to therapy of relapsed and refractory Hodgkin lymphoma.

H3K27M/I mutations promote context-dependent transformation in acute myeloid leukemia with RUNX1 alterations
Mutations in critical histone lysine residues have been demonstrated to contribute to solid tumors but have not been previously described in human leukemia. Lehnertz and colleagues identify H3K27M/I mutations in acute myeloid leukemia in association with RUNX1 gene mutations. This combination accelerates leukemic transformation in mouse models.

Degree of anemia, indirect markers of hemolysis, and vascular complications of sickle cell disease in Africa
There is ongoing controversy about the validity of distinguishing “hyperhemolytic” versus “hyperviscous” phenotypes in sickle cell disease (SCD). Dubert and colleagues examine this issue in more than 2400 patients with SCD from sub-Saharan Africa, demonstrating that severe anemia, but not hemolytic index, predicts for leg ulcers, microalbuminuria, and elevated tricuspid regurgitant jet velocity.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice
CLEC-2 is a platelet receptor that is necessary for both blood and lymph separation during development and for thrombus stability. Using a knock-in model of a mutant CLEC-2 receptor, Haining et al demonstrate that the receptor’s role in blood-lymphatic separation is signaling dependent while its role in thrombus stabilization is signaling independent.

Rituximab-based first-line treatment for chronic GVHD after allogeneic SCT: results of a phase 2 study
Malard et al report on a phase 2 study which demonstrates that the addition of rituximab to steroids and calcineurin inhibitors is safe and effective in first-line treatment of chronic graft-versus-host disease (GVHD).

Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma
In an Evidence-Based Focused Review that is also this month’s CME article, Lin and colleagues report that comprehensive geriatric assessment should be used to identify patients fit for anthracycline-containing treatment regimens, as these patients appear to have improved survival.


This week's complete table of contents

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