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Volume 129, Issue 10

Cover Figure: Confirmation of a marginated pool of monocytes within the vasculature.  See the article by Hamon et al.

WASHINGTON, March 9, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Nonneutralizing antibodies against factor VIII and risk of inhibitor development in severe hemophilia A
In this week’s plenary paper, Cannavò and colleagues examine the significance of nonneutralizing antibodies (NNAs) in predicting factor VIII inhibitor development. They demonstrate that the presence of NNAs before factor VIII exposure moderately increases the rate of subsequent inhibitor formation.

Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab
Abaza et al report that with a mature median follow-up of 4 years, acute promyelocytic leukemia treated with all-trans-retinoic acid and arsenic trioxide with the addition of gemtuzumab for high-risk disease has outstanding and durable responses without chemotherapy.

TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1
Jahn and colleagues report elegant studies identifying a high-affinity T-cell receptor targeting an intracellular B-cell specific transcription factor. T cells expressing this high-affinity receptor eradicate malignant B cells in vitro and in vivo.

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment
There is increasing evidence that adipose tissue plays an important and active role in hematopoiesis. Shafat et al present studies that demonstrate that marrow adipocytes support survival and proliferation of acute myeloid leukemia blasts, which actively induce lipolysis and fatty acid transfer.

Mature CD10+ and immature CD10- neutrophils present in G-CSF–treated donors display opposite effects on T cells
Using elegant in vivo imaging, McDonald and colleagues demonstrate that neutrophil extracellular traps (NETs), platelets, and thrombin collaborate to promote sepsis-associated disseminated intravascular coagulation, adding important data about the broad role for NETs in the inflammatory response.

Splicing factor gene mutations in hematologic malignancies
Saez et al review the role of splicing factor mutation in hematologic malignancies, with emphasis on their functional impact on splicing, their impact on clinical outcomes, and the potential for novel targeting therapies specific for pre-mRNA splicing.

How I manage ibrutinib-refractory chronic lymphocytic leukemia
Relapse following ibrutinib in chronic lymphocytic leukemia is a therapeutic challenge. Woyach uses 3 cases to illustrate the need to accurately diagnose relapse and discusses potential treatment strategies for those patients who lose their response to ibrutinib.

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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