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Volume 129, Issue 23

Cover Figure:  iNK cells, Tregs, and chronic GVHD. See the article by
Du et al.

WASHINGTON, June 8, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients
Based on detailed studies on neutrophils in β-thalassemic mice and in patients with β-thalassemia, Siwaponanan et al offer a potential novel mechanism for the increase in infections observed in patients with the disease.

Genomic architecture and treatment outcome in pediatric acute myeloid leukemia: a Children's Oncology Group report
This “definitive” genome-wide genotyping study in 446 pediatric patients with acute myeloid leukemia evaluates genome copy number variations and their significance for treatment outcome.

Interim PET-driven strategy in de novo diffuse large B-cell lymphoma: do we trust the driver?
The role of positron emission tomography (PET) during treatment of diffuse large B-cell lymphoma in daily practice remains a subject of considerable controversy. In this Perspective, the authors review the limitations and advantages of interim PET in the therapeutic management of malignant lymphoma.

Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation
Lizcano et al present important insights into the direct interactions between red blood cells (RBCs) and neutrophils to modulate inflammation. They demonstrate that RBC sialoglycoproteins engage Siglec-9 on neutrophils to maintain quiescence of neutrophils in the bloodstream.

PD-1 blockade with nivolumab in relapsed/refractory primary central nervous system and testicular lymphoma
This intriguing clinical paper reports PD-1 blockade in 4 patients with relapsing or primary refractory central nervous system (CNS) lymphoma and 1 patient with testicular lymphoma relapsed in the CNS. All patients responded and 4 achieved long-lasting complete remissions.

Molecular convergence in ex vivo models of Diamond-Blackfan anemia
O’Brien and colleagues compare the growth of circulating red cell progenitor cells ex vivo from patients with Diamond-Blackfan anemia with ribosomal protein or GATA1 gene mutations and report altered transcriptional profiles and potential mechanisms underlying dysregulation of translation in erythroid differentiation.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.