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Volume 129, Issue 22

Cover Figure: Bone marrow niche WNT signaling promotes MDS. See the article by Stoddart et al.

WASHINGTON, June 1, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model
In this week’s plenary paper, Stoddart and colleagues use genetic mouse models to demonstrate that WNT signaling from niche cells contributes to myelodysplastic syndromes (MDS), suggesting that WNT downregulation may offer a novel pathway for MDS therapy.

Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy
Lopes et al examine intracranial hemorrhage in the ARISTOTLE trial, which compared the efficacies of apixaban and warfarin for treatment of atrial fibrillation. They report that this devastating complication occurs increasingly with age and concomitant aspirin and that it is less common with apixaban than with warfarin.

Perforin and CD107a testing is superior to NK cell function testing for screening patients for genetic HLH
Decreased NK cell function is one of the HLH94 criteria for the diagnosis of familial hemophagocytic lymphohistiocytosis (HLH). Rubin and colleagues demonstrate that flow cytometry for perforin and CD107a outperforms NK cell functional assays and should probably replace NK cell testing in screening for genetic forms of HLH.

Association of circulating transcriptomic profiles with mortality in sickle cell disease
Desai et al used transcriptomic analysis in a training cohort and two testing cohorts to define a gene expression signature for patients with sickle cell disease that predicts for disease severity and mortality.

How I treat autoimmune hemolytic anemia
Go and colleagues use four illustrative cases to present a practical approach to the evaluation and treatment of autoimmune hemolytic anemia.

Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia
Kruth and colleagues use next-generation sequencing and short hairpin RNA screening to elucidate the mechanism of glucocorticoid activity in acute lymphoblastic leukemia, demonstrating that steroids suppress B-cell developmental genes, an effect that is enhanced by inhibition of PI3Kδ with idelalisib.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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