Advertisement

Volume 131, Issue 23

 

 

June 7, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Clinical trial with a novel IL-15 fusion protein for promoting graft-versus-leukemia.
See the article by Romee et al.

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
In this plenary paper, the authors report the results of the first-in-human clinical trial of a novel interleukin-15 (IL-15) fusion protein to promote graft-versus-leukemia without enhancing graft-versus-host disease in patients with hematologic malignancies who relapsed after allogeneic stem cell transplantation.


Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis
Studies investigating how micronutrients regulate erythropoiesis within the erythroblastic niche have primarily focused on iron homeostasis. Liao et al have discovered novel roles of selenoproteins as critical regulators of stress erythropoiesis.


Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma
These studies reveal a novel mechanism by which Epstein-Barr virus (EBV)–positive lymphoma establishes a pathogenetic tumor microenvironment and suggest future novel therapeutic targets for EBV-positive B-cell lymphoma.


Advances in the treatment of extranodal NK/T-cell lymphoma, nasal type
This comprehensive review describes the therapeutic advances and the clinical approach in extranodal natural killer (NK)/T-cell lymphoma of the nasal type.


Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion
This work shows that transfusion of “old” storage-damaged red blood cells accelerates erythrophagocytosis by splenic red pulp macrophages and monocytes. Increased erythrophagocytosis induces increased production of reactive oxygen species and lipid peroxidation, termed “ferroptosis.”

 

View this week's complete table of contents

Why Submit to Blood?

 


Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.