Advertisement

Volume 131, Issue 26

 

 

June 28, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia.
See the article by Wang et al.

Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT
The reported contributions of the microbiome to transplant outcomes continue to expand. Haak et al present data suggesting that patients with gut colonization with butyrate-producing microbes early after allogeneic transplantation are protected against lower respiratory tract infections.


Oral arsenic and all-trans retinoic acid for high-risk acute promyelocytic leukemia
Zhu and Liu present data on the use of an oral regimen of arsenic and all-trans retinoic acid for high-risk acute promyelocytic leukemia, with over 90% event-free survival and 100% overall survival.


The enigma of monosomy 7
An understanding of the role of monosomy 7 in myeloid malignancy has been elusive. Inuba and colleagues review this perplexing problem, discuss the candidate haploinsufficient genes promoting myeloid transformation, and propose two mechanisms by which those genes act.


Enhanced phosphocholine metabolism is essential for terminal erythropoiesis
Huang et al describe a previously underappreciated role of phosphocholine metabolism in erythroid differentiation. Through studies in knockout mice and primary human stem cell cultures, they demonstrate that PHOSPHO1 is necessary for terminal red cell maturation.


Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease
In this Special Report, Abla et al present consensus recommendations for the diagnosis and management of Rosai-Dorfman-Destombes disease, a rare non–Langerhans cell histiocytosis seen primarily in children and young adults.


Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia
Wang and colleagues report that FOXO1 regulation is required to maintain growth and proliferation of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Though generally presumed to act as a tumor suppressor, FOXO1 inactivation leads to reduced growth and increased apoptosis of tumor cells, suggesting a novel potential therapeutic target for BCP-ALL.


How I treat T-cell chronic active Epstein-Barr virus disease
Chronic active T-cell chronic active Epstein-Barr virus disease (CAEBV) is an aggressive disease in which EBV infects T cells, associated with high viral load and the potential for liver failure, hemophagocytic lymphohistiocytosis, and lymphoma. Bollard and Cohen review their approach to the diagnosis and therapy of CAEBV.


Reactivation of γ-globin in adult β-YAC mice after ex vivo and in vivo hematopoietic stem cell genome editing
Li et al report the first in vivo gene editing in adult β-YAC mice expressing human β-globin. They infused an adenoviral vector expressing a CRISPR/Cas9 construct disrupting the BCL11A-binding site in the γ-globin promoter, with successful activation of the γ-globin gene.

View this week's complete table of contents

Why Submit to Blood?

 


Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.