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Volume 132, Issue 2

 

 

July 12, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Review Series: Nontraditional roles for the hemostatic system in the vessel wall
See the articles in this review series.

Hemostatic efficacy of pathogen-inactivated versus untreated platelets: a randomized controlled trial
van der Meer and colleagues report the results of a randomized trial of pathogen-inactivated platelets vs control platelets with respect to hemostatic efficacy, platelet increments, and development of HLA class I antibodies.


Wnt5a induces ROR1 to recruit DOCK2 to activate Rac1/2 in chronic lymphocytic leukemia
ROR1 is expressed in chronic lymphocytic leukemia (CLL), where higher levels confer a poor prognosis. Hasan and colleagues demonstrate that Wnt signaling can induce ROR1 to complex with DOCK2 and induce Rac1/2 activation, leading to increased CLL cell proliferation. ROR1 may offer a novel target for therapy of CLL.


Metabolic heterogeneity on baseline 18FDG-PET/CT scan is a predictor of outcome in primary mediastinal B-cell lymphoma
By combining fluorodeoxyglucose positron emission tomography (FDG-PET) assessments of metabolic tumor volume with measures of tumor heterogeneity, Ceriani et al developed a model of progression-free survival in primary mediastinal B-cell lymphoma that identifies a subgroup of patients at high risk of progression.


Clonal interference of signaling mutations worsens prognosis in core-binding factor acute myeloid leukemia
Clonal interference is the independent evolution of subclones carrying different gene mutations. Itzykson et al report that over 25% of patients with core-binding factor acute myeloid leukemia have two or more independent subclones of the RTX/RAS pathway and that such clonal interference predicts shorter event-free survival.


IGF-1 facilitates thrombopoiesis primarily through Akt activation
Chen et al demonstrate that insulin-like growth factor 1 (IGF-1) promotes megakaryocyte differentiation, proplatelet formation, and platelet release by a thrombopoietin-independent pathway.


Introduction to a review series on nontraditional roles for the hemostatic system in the vessel wall
This review series explores the growing understanding of the diverse roles of the hemostatic system outside the realm of clotting and bleeding. The reviews explore the important roles of coagulation proteins and platelets in hematopoietic stem cell development, vessel wall formation, vascular endothelial function, and neuroprotection.


The articles in this review series, "Nontraditional roles for the hemostatic system in the vessel wall", include the following:

 

View this week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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