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Volume 130, Issue 26

Cover Figure: VAMP-3 mediates platelet endocytosis and regulates platelet trafficking and function See the article by Kordbacheh et al.

December 28, 2017 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Frontline brentuximab vedotin in combination with dacarbazine or bendamustine in patients aged >60 years with HL
Friedberg and colleagues report on an open-label study of brentuximab vedotin (BV) in combination with dacarbazine (DTIC) or bendamustine in older patients with Hodgkin lymphoma (HL). They demonstrate that BV plus DTIC is well tolerated and yields excellent clinical outcomes in these patients.

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms
Nieborowska-Skorska et al use several preclinical models to demonstrate that ruxolitinib disrupts DNA repair pathways in myeloproliferative neoplasms, promoting synthetic lethality in response to concomitant PARP inhibitors.

Cellubrevin/vesicle-associated membrane protein-3–mediated endocytosis and trafficking regulate platelet functions
Endocytosis is a key process by which platelets acquire serum proteins important for platelet function. Banerjee and colleagues demonstrate that cellubrevin/vesicle-associated membrane protein-3 is a critical regulator of platelet endocytosis that modulates platelet trafficking, platelet function, and thrombopoietin signaling.

SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes
Gogishvili and colleagues show impressive efficacy of SLAMF7-CAR T cells in preclinical models of multiple myeloma.

Immature CML cells implement a BMP autocrine loop to escape TKI treatment
Despite the efficacy of tyrosine kinase inhibitors (TKI) in chronic myeloid leukemia (CML), resistance of the leukemic stem cell persists. Grockowiak et al demonstrate that TKI resistance results from activation of a BMP-dependent autocrine loop.

Extracellular histones induce erythrocyte fragility and anemia
Kordbacheh and colleagues demonstrate in vitro and in vivo that exposure to extracellular histones induces erythrocyte aggregation, increases fragility, and upregulates splenic clearance, potentially explaining acute anemia in the setting of sepsis and other severe illnesses.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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