Volume 132, Issue 26



December 27, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Macrophage TNF-α and bone marrow T cells in the pathogenesis of murine aplastic anemia. See the article by Sun et al.

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation
In a plenary paper, Jacquelin and colleagues report that Dnmt3a deletion in Jak2V617F murine hematopoietic stem cells followed by transplantation into lethally irradiated mice gives rise to a rapidly progressive myelofibrosis.

Hyper-N-glycosylated SAMD14 and neurabin-I as driver autoantigens of primary central nervous system lymphoma
Thurner et al demonstrate that 8 of 12 samples from patients with primary central nervous system lymphoma (PCNSL) had B-cell receptors recognizing hyperglycosylated CNS-restricted proteins SAMD-14 and neurabin-I. These studies provide pathophysiologic insight into the drivers of the disease and its tropism for the CNS. They further offer a potential target for future therapy.

Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
In a Perspective, Dreyling and colleagues discuss the unique challenges of diagnosing and treating blastoid and pleomorphic mantle cell lymphoma, a prognostically unfavorable subtype of the disease.

Macrophage TNF-α licenses donor T cells in murine bone marrow failure and can be implicated in human aplastic anemia
Sun and colleagues demonstrate a role for macrophage tumor necrosis factor α (TNF-α) interacting with TNF receptor–positive T cells in the pathogenesis of murine aplastic anemia and present evidence that this may also be implicated in the human disease.

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice
Bromberger et al demonstrate that Talin1 is critical in the regulation of activity of platelet and neutrophil integrins and, through interactions with Rap1, mediates dynamic integrin-mediated responses.

Nrf2 regulates CD4+ T cell–induced acute graft-versus-host disease in mice
Tsai and colleagues report that nuclear factor erythroid-derived 2-like 2 (Nrf2), an important transcription factor in stem cells and leukocytes, has a previously unrecognized role in T cells in regulating alloreactive responses. Downregulation of Nrf2 activity in T cells offers a novel target for amelioration of graft-versus-host disease.

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