Volume 132, Issue 24



December 13, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: The ubiquitinating enzyme UCH-L1 in murine MYC-driven lymphoma. See the article by Hussain et al.

UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice
Hussain et al demonstrate that the deubiquitinating enzyme UCH-L1 is required for MYC-driven lymphomas. They further show that UCH-L1 acts by modulating mTOR signaling both to enhance survival and proliferation and to activate a novel translation initiation pathway to increase protein synthesis.

Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia
Liao and colleagues analyzed murine stress hematopoiesis in the spleen. They demonstrate that monocytes are recruited from the blood and mature into macrophages within blood islands in concert with the maturation of stress erythroid progenitors.

Mechanisms of receptor shedding in platelets
Regulation of platelet adhesive and procoagulant properties is modulated by shedding of adhesion receptors from the platelet surface. Montague and colleagues review our current understanding of receptor regulation by metalloproteases that influence receptor density and platelet function.

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding
In an analytic tour de force, Baaten et al scored and synthesized the results of more than 1500 studies involving over 400 mouse genes to characterize a network of protein interactions mediating hemostasis and thrombosis. In an e-Blood article, they identify candidate proteins shared by humans that provide potential therapeutic targets for improved antithrombotic therapy.

Unrelated donor vs HLA-haploidentical α/β T-cell– and B-cell–depleted HSCT in children with acute leukemia
Bertaina et al compare haploidentical α/β T-cell– and B-cell–depleted hematopoietic stem cell transplantation (HSCT) to matched and mismatched unrelated donor HSCT in children with acute leukemia. They demonstrate that survival and rates of acute and chronic graft-versus-host disease with haploidentical transplantation are equivalent to those in matched and superior to outcomes in mismatched unrelated donor HSCT.

Unique dependence on Sos1 in KrasG12D-induced leukemogenesis
Mutant Kras is implicated in aggressive myeloproliferative disease in mice and humans, including juvenile myelomonocytic leukemia. You et al demonstrate that signaling through mutant Kras is uniquely dependent on Sos1, highlighting a potential novel therapeutic target for Kras-mutant myeloproliferative neoplasms.

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