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Volume 132, Issue 9

 

 

August 30, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Key role of oncogenic mutations in pathogenesis of ATLL. See the article by Ng et al.

Intravenous immunoglobulin vs observation in childhood immune thrombocytopenia: a randomized controlled trial
This plenary paper presents the long-awaited results of an important randomized, controlled trial comparing intravenous immunoglobulin with observation in children with immune thrombocytopenia (ITP) at diagnosis, and it reports the frequency of chronic ITP in treated and untreated children.


SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice
This study elegantly demonstrates that steroid receptor coactivator 3 (SRC-3) is essential for maintenance of hematopoietic stem cell homeostasis via repression of mitochondrial biogenesis.


Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease
This article reports that somatic genetic variants other than BCR-ABL1 are frequently found in patients with newly diagnosed chronic myeloid leukemia (CML) with a poor response to tyrosine kinase inhibitor therapy.


High-risk chronic lymphocytic leukemia in the era of pathway inhibitors: integrating molecular and cellular therapies
In this Special Report, experts on chronic lymphocytic leukemia (CLL) present a clinically relevant consensus statement that reclassifies high-risk CLL patients in the context of current management with pathway inhibitors and chemoimmunotherapy.


The role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis
This review discusses the status of diagnostic ADAMTS13 testing, both quantitative and functional, in thrombotic thrombocytopenic purpura (TTP) and other microangiopathic conditions.


RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice
The investigators address the key role of particular oncogenic mutations in the pathogenesis of adult-type lymphoma/leukemia.


Structure of an extended β3 integrin
This work reveals that conformational extension is essential for β3 integrin to fulfill its cell adhesion function in platelet-mediated hemostasis and thrombosis.

View this week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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