Volume 132, Issue 8



August 23, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: CTCF boundary modulates HOX gene transcription in AML. See the article by Luo et al.

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL
Rossi and colleagues used single-cell analysis of chimeric antigen receptor (CAR) T-cell products to define their functional heterogeneity. They demonstrate that the “polyfunctionality strength index” predicts both tumor response and cytokine toxicity.

Translating anti-CD19 CAR T-cell therapy into clinical practice for relapsed/refractory diffuse large B-cell lymphoma
In this Blood Spotlight, Chow et al provide a state-of-the-art review of the role of CAR T cells in the therapy of relapsed/refractory diffuse large B-cell lymphoma.

Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment
Cader et al investigated the basis of the defective immune response against Hodgkin lymphoma (HL), demonstrating that the infiltrating T lymphocytes in the HL microenvironment are exhausted PD-1+ Th1 effector cells and active PD-1 Th1 regulatory T cells.

Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways
Using a nonhuman primate model, Popescu et al demonstrate that a Bacillus anthracis–derived protein interacts with the coagulation system to promote sepsis-related coagulopathy.

ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition
Roberts and colleagues describe a conditional knockin model of ETV6-NTRK3 acute lymphoblastic leukemia (ALL), a subtype of BCR-ABL–like ALL. They demonstrate that it can serve as a useful tool for testing potential tyrosine kinase inhibitor therapy for this subtype of ALL.

Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal
Shepherd and colleagues used single-cell expression and functional activity to identify genes that promote stem cell self-renewal in JAK2V617F myeloproliferative neoplasms.

How I treat primary mediastinal B-cell lymphoma
Giulino-Roth describes her treatment approach to primary and relapsed primary mediastinal B-cell lymphoma through the discussion of 2 illustrative cases.

View this week's complete table of contents

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