Advertisement

Volume 132, Issue 8

 

 

August 23, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: CTCF boundary modulates HOX gene transcription in AML. See the article by Luo et al.

Preinfusion polyfunctional anti-CD19 chimeric antigen receptor T cells are associated with clinical outcomes in NHL
Rossi and colleagues used single-cell analysis of chimeric antigen receptor (CAR) T-cell products to define their functional heterogeneity. They demonstrate that the “polyfunctionality strength index” predicts both tumor response and cytokine toxicity.


Translating anti-CD19 CAR T-cell therapy into clinical practice for relapsed/refractory diffuse large B-cell lymphoma
In this Blood Spotlight, Chow et al provide a state-of-the-art review of the role of CAR T cells in the therapy of relapsed/refractory diffuse large B-cell lymphoma.


Mass cytometry of Hodgkin lymphoma reveals a CD4+ regulatory T-cell–rich and exhausted T-effector microenvironment
Cader et al investigated the basis of the defective immune response against Hodgkin lymphoma (HL), demonstrating that the infiltrating T lymphocytes in the HL microenvironment are exhausted PD-1+ Th1 effector cells and active PD-1 Th1 regulatory T cells.


Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways
Using a nonhuman primate model, Popescu et al demonstrate that a Bacillus anthracis–derived protein interacts with the coagulation system to promote sepsis-related coagulopathy.


ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition
Roberts and colleagues describe a conditional knockin model of ETV6-NTRK3 acute lymphoblastic leukemia (ALL), a subtype of BCR-ABL–like ALL. They demonstrate that it can serve as a useful tool for testing potential tyrosine kinase inhibitor therapy for this subtype of ALL.


Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal
Shepherd and colleagues used single-cell expression and functional activity to identify genes that promote stem cell self-renewal in JAK2V617F myeloproliferative neoplasms.


How I treat primary mediastinal B-cell lymphoma
Giulino-Roth describes her treatment approach to primary and relapsed primary mediastinal B-cell lymphoma through the discussion of 2 illustrative cases.

View this week's complete table of contents

Why Submit to Blood?

 


Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.