Volume 131, Issue 17



April 26, 2018 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Myosin 1f is crucial for neutrophil trafficking during inflammation.
See the article by Salvermoser et al.

Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation
In a plenary paper, the investigators demonstrate that an unconventional class I myosin, myosin 1f, is crucial for the dynamics of the deformation of the neutrophil nucleus and for neutrophil trafficking during acute inflammation in vascular beds in vivo.

Single-agent ibrutinib in treatment-naïve and relapsed/refractory chronic lymphocytic leukemia: a 5-year experience
The authors report on long-term efficacy and safety of ibrutinib in a 5-year follow-up of the first cohort of treated patients with chronic lymphocytic leukemia.

Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus
The investigators used an innovative genome editing approach to induce fetal hemoglobin, which may lead to therapeutic strategies for sickle cell disease and β-thalassemia.

Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib
This detailed report discusses more than 30 patients who developed invasive fungal infections, particularly invasive aspergillosis, during ibrutinib treatment. The study supports the notion that fungal infections are a serious potential risk associated with the use of ibrutinib.

The search for new antithrombotic mechanisms and therapies that may spare hemostasis
Glycoprotein Ibα (GPIbα) on platelets binds αMβ2 (Mac-1) on leukocytes to form platelet-leukocyte aggregates that promote thrombosis and inflammation. In this Blood Spotlight, the authors discuss how targeting the GPIbα–Mac-1 interaction may attenuate thrombosis and atherosclerosis while preserving hemostasis.

Coagulation factor XII in thrombosis and inflammation
The authors review the important recent advances in our understanding of the role of factor XII and the contact pathway in thrombosis. The identification of the role of platelet polyphosphate in mediating factor XII activation and initiating thrombosis suggests new targets for intervention.


View this week's complete table of contents

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