Volume 133, Issue 15



April 11, 2019 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Cover Figure: Critical and novel insights into the mechanistic etiology of myelofibrosis. See the article by Wakahashi et al.

Vitamin D receptor–mediated skewed differentiation of macrophages initiates myelofibrosis and subsequent osteosclerosis
This Plenary Paper presents novel insights into the pathogenesis of bone marrow fibrosis in JAK2V617F-driven myeloproliferative neoplasia. Drawing on a series of elegant experiments in mouse models, the investigators provide compelling evidence for the critical role of the nuclear vitamin D receptor and bone marrow macrophages in the pathogenesis of idiopathic myelofibrosis.

Characterization and treatment of congenital thrombotic thrombocytopenic purpura
The authors report important clinical information indicating that ~30% of patients with congenital thrombotic thrombocytopenic purpura have persistent symptoms of headache, lethargy, and abdominal pain and are responsive to prophylactic therapy.

Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR T-cell therapy
This is the first study that looks specifically at factors associated with durable event-free survival (EFS), including minimal residual disease (MRD) negativity, in patients with acute lymphoblastic leukemia (ALL) undergoing CD19 chimeric antigen receptor (CAR) T-cell therapy.

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet
Significant advances have been made recently in the treatment of acute promyelocytic leukemia (APL). This Special Report presents a timely update of European LeukemiaNet’s recommendations for the management of APL..

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma
This study investigated the chromosomal gains and losses of peripheral T-cell lymphoma (PTCL). The results indicate differences in pathogenesis of previously gene expression–defined PTCL subtypes. These molecular pathogenesis-relevant subtypes will likely set a new standard for diagnosis.

Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition
This paper presents promising results with MAPK-pathway inhibitory treatment in children with neurodegenerative Langerhans cell histiocytosis (LCH).

View this week's complete table of contents

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