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Issue 21, Volume 128

Cover Figure:  Platelets releasing thrombotic mediators through 2 pathways of exocytosis.  See the article by Eckly et al.

WASHINGTON, November 24, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Refinement of the Lugano Classification lymphoma response criteria in the era of immunomodulatory therapy
Cheson and colleagues offer novel criteria for response to treatment that are crucial to many aspects of the evolving management of lymphoid malignancy.

Interferon-free antiviral treatment in B-cell lymphoproliferative disorders associated with hepatitis C virus infection
Arcaini et al demonstrate that patients with indolent B-cell non-Hodgkin lymphomas associated with chronic hepatitis C virus (HCV) infection can achieve both virological and lymphoma responses when treated with highly-effective, novel HCV eradication therapy.

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes
Urrutia et al identify the brain pericyte as an oxygen sensor and a novel erythropoietin-producing cell in the brain.

A trial of unrelated donor marrow transplantation for children with severe sickle cell disease
The first prospective trial of unrelated donor bone marrow transplantation in children with sickle cell disease marks an important step in extending curative therapy to more children with this severe disease.

Discussing and managing hematologic germ line variants
With the introduction of genomic technologies, more hereditary cancer syndromes with hematological malignancies are being described. The authors address the difficult task of explaining complex genetic information and the associated inherited risks to patients and their families.

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells
The authors provide a comprehensive analysis of the transcriptional profiles of nonhuman primates and patients with graft-versus-host disease (GVHD) that supports the role of the Th/Tc17 pathway in GVHD progression.

Identification of glycans on plasma-derived ADAMTS13
In an e-Blood article, Verbij et al identify the site of glycosylation on plasma ADAMTS13 and determine the composition of the glycan structure at these sites.

Respective contributions of single and compound granule fusion to secretion by activated platelets
Platelet secretion of granule contents is important for hemostasis and thrombosis; nevertheless, the routes through which the contents of platelet α and δ granules are released are unclear. The investigators postulate that platelets release mediators through two distinct processes of membrane fusion: single and compound exocytosis.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

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