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Issue 20, Volume 128

Cover Figure: Platelet-derived HMGB1 coordinates venous thrombosis in mice.  See the article by Stark et al.

WASHINGTON, November 17, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin- and bradykinin-dependent mechanism
Marcos-Contreras and colleagues report that activation of fibrinolysis increases blood-brain barrier permeability by the direct activation of bradykinin. This increased permeability may explain complications of tissue-type plasminogen activator (tPA) infusion such as central nervous system bleeding and angioedema.

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice
Stark and colleagues provide further evidence for the intimate relationship between thrombosis and inflammation. They demonstrate that platelet-derived damage associated molecular pattern protein HMGB1 coordinates venous thromboembolism–associated sterile inflammation by inducing neutrophil extracellular trap formation, platelet aggregation, and monocyte activation.

Enhanced in utero allogeneic engraftment in mice after mobilizing fetal HSCs by α4β1/7 inhibition
Kim and colleagues report successful in utero engraftment in mice using CXCR4 and α4β1 and α4β7 inhibitors to mobilize fetal stem cells prior to injection of adult hematopoietic stem cells (HSCs), creating “space” that allows successful competition by adult HSCs.

When clinical heterogeneity exceeds genetic heterogeneity: thinking outside the genomic box in chronic myelomonocytic leukemia
In a Perspective piece, Ball and colleagues discuss the apparent paradox in the clinical and molecular features of chronic myelomonocytic leukemia, which demonstrates enormous clinical heterogeneity despite its surprisingly limited mutational landscape.

How I treat essential thrombocythemia
Rumi and Cazzola use 5 cases to highlight the evaluation and treatment of patients with essential thrombocythemia. They provide a roadmap for the diagnostic workup and therapeutic approach to these patients.

Thrombosis in the setting of obesity or inflammatory bowel disease
Obesity and inflammatory bowel disease are chronic inflammatory disorders predisposing to arterial and venous thrombosis. Lentz provides an overview of the indications for and management of anticoagulation in these challenging patients.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

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