Issue 9, Volume 127

Cover Figure: Mechanism of VWF dimerization.See the article by Lippok et al.

WASHINGTON, March 3, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo
In their plenary paper in this week's Blood, Motley et al identify a novel intracellular plasminogen-dependent fibrin degradation pathway in a specific proinflammatory macrophage population. The unexpected mechanism for clearance of extravascular fibrin is accomplished in CCR2 and CX3CR1 double-positive macrophages and depends upon active plasmin, yet it is independent of known fibrinogen receptors.

Influence of immunoglobulin isotype on therapeutic antibody function
In a succinct Blood Spotlight, Beers et al discuss the impact of immunoglobulin isotype selection on the therapeutic efficacy of antibodies in oncology. The authors highlight the importance of considering the choice of isotype in selecting optimal agents with appropriate functional properties.

Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma

Melphalan, prednisone, and lenalidomide versus melphalan, prednisone and thalidomide in untreated multiple myeloma
In this issue of Blood, Magarotto et al report the results of a phase 3 randomized trial directly comparing the therapeutic value of three different lenalidomide-based combinations in elderly patients with newly diagnosed multiple myeloma. Also in this issue, Zweegman et al present the results of another phase 3 randomized trial comparing head to head melphalan-prednisone-thalidomide with melphalan-prednisone-lenalidomide in the same category of patients.

Circular RNA enrichment in platelets is a signature of transcriptome degradation
In an e-Blood article, Alhasan et al report the existence of circular RNAs in circulating human platelets, thus revealing yet another fascinating facet of their already diverse transcriptome.

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria
O'Regan and coworkers extend our understanding of von Willebrand factor (VWF) in the pathogenesis of malaria. Their data help clarify whether VWF levels are an effect or a cause of decreased malaria resistance.

Mouse host unlicensed NK cells promote donor allogeneic bone marrow engraftment
Alvarez et al describe a novel inhibitory receptor-mediated role for unlicensed natural killer cells in the facilitation of allogeneic engraftment, and they offer insights of significant translational importance for clinical transplantation.

This week's complete table of contents

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Blood (, the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (, the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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