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Issue 8, Volume 128

Cover Figure: Fibrinogen binding to
β-amyloid. See the article by Zamolodchikov et al.

WASHINGTON, August 25, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation
Most expression profiling of hematopoietic stem and progenitor cells (HSPCs) has analyzed sorted subsets of cell populations rather than individual cells. In a plenary e-Blood article, Nestorowa and colleagues exploit new single-cell profiling techniques to catalog gene expression changes of individual cells to refine our understanding of the gene expression changes that occur in early HSPC differentiation.

Autologous hematopoietic cell transplantation for HIV-related lymphoma: results of the BMT CTN 0803/AMC 071 trial
In many centers, HIV infection is considered a contraindication for autologous hematopoietic cell transplantation (AHCT) for patients with lymphoma. Alvarnas and colleagues report the results of a multicenter phase 2 trial of AHCT for patients with HIV-related lymphoma, demonstrating outcomes equivalent to those in HIV-negative lymphoma without loss of viral control of HIV.

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms
Nearly all patients with polycythemia vera and more than half of patients with essential thrombocytosis and myelofibrosis carry JAK2 V617F. Hinds and colleagues identify germ line variants of several genes that are associated with JAK2 V617F clonal hematopoiesis and myeloproliferative disease; furthermore, they confirm age-related JAK2 V617F in 0.2% of the general population. These results link age-related clonal hematopoiesis to the development of myeloproliferative neoplasms.

Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells
There is increasing evidence for wide-ranging signaling functions for coagulation proteins beyond their role in coagulation and fibrinolysis. Dhahri and colleagues demonstrate that tissue plasminogen activator, in association with matrix metalloproteinase 9, expands mesenchymal stem cells. This adds to our growing understanding of the cross talk between fibrinolysis and cytokine interaction within the bone marrow niche.

Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice
Administration of polyclonal anti-D effectively prevents hemolytic disease of the fetus and newborn (HDFN), but a recombinant alternative has been elusive. Single monoclonal antibodies reduce but do not prevent the development of anti-D antibodies that can cause HDFN. Bernardo and colleagues demonstrate that murine anti-D immunization is more effectively eliminated by administration of combinations of monoclonal antibodies targeting different epitopes.

CHAI and LATAIE: new genetic diseases of CTLA-4 checkpoint insufficiency
In this review, Lo and colleagues describe 2 newly-characterized immunodeficiency syndromes that cause CTLA-4 deficiency. They illustrate the critical role of CTLA-4 in immune checkpoint regulation and how CTLA-4 deficiency can mimic complications of therapy with novel CTLA-4 checkpoint inhibitors.

Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK kinase pathway mutations

Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene
Two articles describe the genomic landscape of pediatric-type follicular lymphoma (PTFL). They report that PTFL is a unique subtype of lymphoma with a genomic profile completely distinct from that of classical adult follicular lymphoma. This good-prognosis subtype of lymphoma must be characterized by genomic analysis, since it can occur at all ages.

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.