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Issue 14, Volume 127

Cover Figure: Jun/ATF complexes as powerful drivers of survival and proliferation of DLBCL. See the article by Juilland et al.

WASHINGTON, April 7, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets
In their plenary paper in this week's Blood, Rowley et al report that noncoding RNAs precisely regulate the RNA profile in platelets. Interfering in this process by using genetically engineered mice profoundly impacts hemostatic and thrombotic functions of platelets.

Long-acting recombinant coagulation factor IX albumin fusion protein (rIX-FP) in hemophilia B: results of a phase 3 trial
In their phase 3 study, Santagostino et al demonstrate the efficacy and safety of recombinant factor IX-albumin fusion (rIXFP). Along with the other 2 extended-half-life FIX products recently approved, this agent heralds a new era for the treatment of hemophilia B.

CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas
Juilland and colleagues reveal the expression pattern and the role of different members of the ATF transcription factor family in the survival of diffuse large B-cell lymphoma (DLBCL) cells. These data indicate that Jun/ATF complexes are important drivers of survival and proliferation of activated B-cell type DLBCL, and they importantly add to our understanding of the survival signaling pathways used by lymphoma cells.

Should IGHV status and FISH testing be performed in all CLL patients at diagnosis? A systematic review and meta-analysis
In an Evidence-Based Focused Review, Parikh and colleagues examine the role of immunoglobulin heavy-chain variable-region gene (IGHV) mutation status and genetic abnormalities determined by interphase fluorescence in situ hybridization (FISH) in newly diagnosed patients with chronic lymphocytic leukemia (CLL).

Long-term treatment follow-up of children with sickle cell disease monitored with abnormal transcranial Doppler velocities
Bernaudin et al report that chronic red blood cell transfusions can be safely circumvented with hydroxyurea therapy or bone marrow transplantation for a cohort of children with sickle cell anemia and abnormal transcranial Doppler velocities.

CD8+ T cells mediate antibody-independent platelet clearance in mice
In their work presented in this issue of Blood, Arthur et al show that HLA alloantibodies cannot solely account for the immune mechanism in platelet refractoriness.

Polycomb-dependent epigenetic landscape in adult T-cell leukemia
This report by Fujikawa et al demonstrates that Tax induces a powerful epigenetics-dependent global modification of host gene expression in adult T-cell leukemia (ATL) through either upregulation or downregulation. These findings provide a strong rationale for directly targeting the Tax global fingerprint on cellular genes in ATL therapy.

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

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