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Issue 15, Volume 127

Cover Figure: Novel role of caveolin-1 in control of alloreactive T cells and GVHD.  See the article
by Schönle et al
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WASHINGTON, April 14, 2016 – Welcome to “This Week in Blood,” a weekly snapshot of the hottest studies from each week’s issue of Blood, the official journal of the American Society of Hematology (ASH), hand-picked by Blood Editor-in-Chief Bob Löwenberg, MD, PhD, and Deputy Editor Nancy Berliner, MD.

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders
In their plenary paper in this issue of Blood, Tie and colleagues report the development of a cleverly engineered, cell-based system for studying mutations in γ-glutamyl carboxylase (GGCX), the enzyme responsible for converting glutamate residues in certain proteins to γ-carboxyglutamate. They use this cell-based assay system to help explain the clinical manifestations of some otherwise puzzling GGCX gene mutations in humans that cause phenotypes ranging from severe bleeding to Keutel syndrome.

Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms
Loss of responsiveness to treatment with monoclonal antibodies such as rituximab is a serious complication during therapy of B-cell malignancies, but its underlying mechanisms are not well-understood. Lykken et al use an immunocompetent mouse model of B-cell lymphoma to discover a new way in which these malignant cells can avoid being killed in the presence of anti-CD20 antibodies.

Novel genetic predictors of venous thromboembolism risk in African Americans
African Americans experience higher rates of venous thromboembolism (VTE) than their white American counterparts. Hernandez et al identify and replicate single-nucleotide polymorphisms on chromosome 20 (and putatively on the THBD gene for thrombomodulin) that increase the risk of VTE by about 2.3-fold in African Americans.

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype
Jain and colleagues report one of the largest studies that reports clinical data in adult T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma with an immunophenotypically well-characterized cohort. Their study confirms that an early T-cell precursor immunophenotype in adult T-ALL is prognostically relevant.

The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib
This study by Parker et al addresses the prognostic impact of low-level BCR-ABL1 mutations on the response to ponatinib in a study of 363 tyrosine kinase inhibitor–resistant patients with chronic myeloid leukemia.

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells
Schönle et al report a novel role for the membrane organizer caveolin-1 in the control of T-cell fate toward a regulatory phenotype. This impacts a significant increase in the frequency of regulatory T cells, modulates the response of alloreactive T cells, and reduces graft-versus-host disease in vivo.

 

This week's complete table of contents

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Blood (www.bloodjournal.org), the most cited peer-reviewed publication in the field of hematology, is available weekly in print and online. Blood is the official journal of the American Society of Hematology (ASH) (www.hematology.org), the world’s largest professional society concerned with the causes and treatment of blood disorders.

ASH’s mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems by promoting research, clinical care, education, training, and advocacy in hematology.

blood® is a registered trademark of the American Society of Hematology.