Advertisement

Review Series

 

Jump To:

 

The Blood Review Series are collections of articles that highlight topics of significant interest in the field of hematology. Each series provides concise, critical, and insightful overviews of emerging advances in areas of basic or clinical research.

Precision Hematology

Edited with an introduction by Dr Benjamin L. Ebert, we present a series of reviews focused on precision hematology. This series presents the state of the art usage of genomic techniques for the identification of inherited and acquired mutations guiding the diagnosis and treatment of hematologic disorders, the methods for gathering and storing genomic data, and the ethical considerations in such genomic testing.

Published July 27, 2017 - Blood 130:4

 

Clinical Platelet Disorders

Introduced by José López and Nancy Berliner, this series of review articles provides an up-to-date examination of several clinical platelet disorders that often perplex clinicians because of their difficulty in diagnosis or complexity in therapy.

Published May 25, 2017 - Blood 129:21

 

Transcription Factors in Hematopoiesis and Hematologic Disease

Introduced by David Bodine, this set of 6 review articles focuses on 4 hematopoietic transcription factors with critical roles in normal and malignant hematopoiesis. The reviews highlight the fast-moving field of transcription factor biology that is reshaping our understanding of normal and malignant hematology.

Published April 13, 2017 - Blood 129:15

 

Leukemic Stem Cells

Introduced by Bob Löwenberg, this review series on leukemic stem cells, is a collection of definitive reviews on the biology of stem cells in acute myeloid leukemia, myelodysplasia, and myeloproliferative neoplasms, including their relationship to the marrow microenvironment and their significance for effective leukemia treatment.

Published March 23, 2017 - Blood 129:12

 

T-Cell Malignancies

This series of comprehensive reviews discusses the molecular pathobiology and molecular genetics of the highly diverse T-cell malignancies, outlines their diagnostic implications, and highlights novel therapeutic strategies.

Published March 2, 2017 - Blood 129:9

 

Myeloproliferative Neoplasms

Introduced by Dr. Mario Cazzola this comprehensive review series on myeloproliferative neoplasms provides an update on the rapidly evolving understanding of the genetic underpinnings of these diseases and its impact on improving therapy.

Published February 9, 2017 - Blood 129:6

 

Chronic GVHD: From Pathogenic B-cell Receptor to Novel Therapeutic Targets

New directions of research discussed in this series of reviews aim at targeting B-cell signaling pathways that are operational in chronic graft-versus-host disease (cGVHD).

Published January 5, 2017 - Blood 129:1

 

Advances in Cell-Based Immune Therapeutics in Hematology

This six-part series, written by leading experts in the field of cell-based immunotherapy, presents three articles discussing the state of the art of chimeric antigen receptor T-cell therapies and their toxicities and three additional articles that highlight other new immunotherapeutic approaches, including cellular therapies to treat post–hematopoietic stem cell transplantation viral infections, natural killer cell therapies for acute leukemia, and the use of gene-modified T cells to block immune evasion in hematologic malignancies.

Published June 30, 2016 - Blood 127:26

 

Genome Editing in Hematology

The exciting new field of genome editing represents a quantum leap for biology and medicine. A series of four reviews written by experts in the field summarize conceptual, clinical, and ethical aspects of genome editing with a focus on its potential for treating hematologic diseases.

Published May 26, 2016 - Blood 127:21

 

Updated WHO Classification of Hematological Malignancies

Experts in the field summarize the Updated World Health Organization (WHO) Classification of Hematological Malignancies that incorporates new clinical, prognostic, morphologic, immunophenotypic, and genetic data.

Published May 19, 2016 - Blood 127:20

 

The Paradox of Indolent B-cell Lymphoma

A comprehensive series of 5 reviews, introduced by Dr. Laurie Sehn, explore the unique biology and management aspects for indolent B-cell lymphoma subtypes.

Published April 28, 2016 Blood 127:17

 

Megakaryocytes to Platelets in Health and Disease

In this review series, introduced by Dr. Leslie Parise, Blood presents a collection of articles focused on megakaryocytes and platelets and their potential development as in vitro resources for transfusion and for drug delivery.

Published March 10, 2016 - Blood 127:10

 

Sickle Cell Disease: Challenges and Progress

In this review series, introduced by Dr. Leslie Parise and Dr. Nancy Berliner, leading researchers provide five state-of-the-art updates on important biological, clinical, and therapeutic aspects of sickle cell disease.

Published February 18, 2016: Blood 127:7

 

Advances in Acute Myeloid Leukemia

Introduced by Dr. Bob Löwenberg and Dr. Jacob Rowe, this review series offers comprehensive updates on the latest insights into the pathobiology of the disease as well as the current and emerging directions of treatment.

Published January 7, 2016 - Blood 127:1

 

Chronic Lymphocytic Leukemia: Taking a Big Leap Forward

Introduced by Dr. John C. Byrd this review series provides a comprehensive update on the newest insights into the biology of chronic lymphocytic leukemia (CLL) and the emerging treatment scenarios in clinical practice.

Published July 23, 2015 - Blood 126:4

 

Acute Lymphoblastic Leukemia

Introduced by Dr. Jean Soulier and Dr. Jorge Cortes, this review series highlights recent advances in the field of acute lymphoblastic leukemia (ALL) and their impact on developmental therapeutics. They address molecular precision diagnostics, minimal residual disease detection, genetic variation in childhood ALL, and the newest immunotherapeutic approaches.

Published June 25, 2015 - Blood 125:26

 

Multiple Myeloma: From the Bench to Bedside

In this review series, introduced by Dr. Jesús San Miguel, leaders in the field of multiple myeloma (MM) discuss the fascinating pathogenetic scenarios of disease development, the evolution of monoclonal gammopathy of undetermined significance and smoldering myeloma to MM, the clinical importance and practice of minimal residual disease response assessment, and current first- and second-line therapeutic strategies.

Published May 14, 2015 - Blood 125:20

 

Hematopoietic Stem Cells

Introduced by Dr. Margaret Goodell, this review series describes the state of our knowledge of the ontogeny and regulation of hematopoietic stem cells (HSCs) and the role of the bone marrow niche in their development. Other articles discuss xenograft models for studying normal and malignant stem cells and the current state of the art of generation of stem cells from somatic and pluripotent stem cell sources.

Published April 23, 2015 - Blood 125:17

 

Inherited Bleeding Disorders

Edited and introduced with an editorial by Dr. David Lillicrap, this series reviews the state of the art, basic understanding, and clinical management of von Willebrand disease, hemophilia, and other rare bleeding disorders. It includes the latest molecular understanding of the pathogenesis of congenital bleeding diatheses and recommendations for diagnosis and management, including a therapeutic approach to prophylaxis of bleeding and the clinical management of treatment-induced inhibitors.

Published March 26, 2015 - Blood 125:13

 

Aggressive B-cell Lymphoma

The term 'aggressive B-cell lymphomas' has been applied to highly proliferative lymphomas that evolve clinically over weeks to months, and have been the focus of important advantages in clinical treatment strategies. The series highlights the evolution of our understanding of the biology of these lymphomas such that they are now defined as a heterogeneous group of diseases that requires tailored therapy. The aim of the series is to elucidate how this improved understanding of pathogenesis is leading to more effective treatment strategies and improved survival.

Published January 1, 2015 - Blood 125:1

 

Bone Marrow Failure

Bone marrow failure syndromes are characterized by deficient regenerative or maturation abilities of stem and progenitor cells, leading to quantitative and qualitative abnormalities in one or more of the hematopoietic lineages, as well as an increased risk of transformation to leukemia. Recent research has greatly enhanced our understanding of these disorders, leading to better therapies and better clinical outcomes. This series presents comprehensive updates regarding the biology as well as the diagnostic and therapeutic advances in these diseases.

Published October 30, 2014 - Blood 124:18

 

Advances in Hematopoietic Cell Transplantation

This review series provides a perspective on the successes and challenges of Hematopoietic Cell Transplantation. Despite the amazing progress over the last 40 years that has made HCT a “routine” medical procedure, issues surrounding donor choice, conditioning regimens, and management of graft-versus-host disease persist. In this series, experts from around the world provide insights into the current state of the art of HCT and perspectives on future directions.

Published July 17, 2014 - Blood 124:3

 

Antibody Derivatives as New Therapeutics for Hematologic Malignancies

In this review series a variety of antibody-derived therapeutics that show promise for the treatment of hematologic malignancies are reviewed in depth.

Published April, 2014 Blood - 123:15-17