Review Series - March 26, 2015

Edited and introduced with an editorial by Dr David Lillicrap, this series reviews the state of the art, basic understanding, and clinical management of von Willebrand disease, hemophilia, and other rare bleeding disorders. It includes the latest molecular understanding of the pathogenesis of congenital bleeding diatheses and recommendations for diagnosis and management, including a therapeutic approach to prophylaxis of bleeding and the clinical management of treatment-induced inhibitors.


von Willebrand factor biosynthesis, secretion, and clearance: connecting the far ends
Peter J. Lenting, Olivier D. Christophe, and Cécile V. Denis


Diagnostic approach to von Willebrand disease
Christopher Ng, David G. Motto, and Jorge Di Paola