Review Series - October 30, 2014

Bone marrow failure syndromes are characterized by deficient regenerative or maturation abilities of stem and progenitor cells, leading to quantitative and qualitative abnormalities in one or more of the hematopoietic lineages, as well as an increased risk of transformation to leukemia. Recent research has greatly enhanced our understanding of these disorders, leading to better therapies and better clinical outcomes. This series presents comprehensive updates regarding the biology as well as the diagnostic and therapeutic advances in these diseases.


Bone marrow failure and the telomeropathies
Danielle M. Townsley, Bogdan Dumitriu, and Neal S. Young


Marrow failure: a window into ribosome biology
Davide Ruggero and Akiko Shimamura


Recent developments in myelodysplastic syndromes
Rafael Bejar and David P. Steensma



Stress and DNA repair biology of the Fanconi anemia pathway
Simonne Longerich, Jian Li, Yong Xiong, Patrick Sung, and Gary M. Kupfer


See a full listing of the Blood Review Series here