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Review Series - October 30, 2014

Bone marrow failure syndromes are characterized by deficient regenerative or maturation abilities of stem and progenitor cells, leading to quantitative and qualitative abnormalities in one or more of the hematopoietic lineages, as well as an increased risk of transformation to leukemia. Recent research has greatly enhanced our understanding of these disorders, leading to better therapies and better clinical outcomes. This series presents comprehensive updates regarding the biology as well as the diagnostic and therapeutic advances in these diseases.

 

Bone marrow failure and the telomeropathies
Danielle M. Townsley, Bogdan Dumitriu, and Neal S. Young

 

Marrow failure: a window into ribosome biology
Davide Ruggero and Akiko Shimamura

 

Recent developments in myelodysplastic syndromes
Rafael Bejar and David P. Steensma