Table 1

Iron absorption and iron status markers with increasing oral doses of FeSO4 in young women (study 1)

Iron bioavailabilityIron status
Fe dose (mg)DayFractional Fe absorption (%)*Fe absorbed (mg)*PHep (nM)*Plasma Fe (µg/mL)Transferrin saturation (%)PF (µg/L)*sTfR (mg/L)Body iron stores (mg/kg BW)
401NANA0.30 (0.12-0.48)0.63 (0.34)20.9 (15.1)10.0 (3.4-21.8)8.2 (4.2)−0.05 (3.7)
222.7 (14.7-57.1)9.1 (5.8-22.8)0.35 (0.11-0.77)0.55 (0.35)16.5 (11.7)9.1 (4.9-25.4)8.4 (3.8)−0.8 (3.7)
919.4 (15.8-22.9)7.8 (6.3-9.2)0.59 (0.19-4.6)0.67 (0.61)21.3 (24.6)10.3 (5.1-40.8)7.1 (3.2)0.11 (4.1)
1016.7 (11.8-20.7)6.7 (4.7-8.3)0.45 (0.05-4.3)0.60 (0.4)18.6 (16.3)15 (8.4-51.6)7.8 (3.5)1.2 (3.6)
23NANANDNDND7.7 (4.2-20.1)5.6 (1.9)−0.64 (2.4)
801NANA0.93 (0.1-3.7)1.2 (1.1)29.8 (12.8)19.4 (6.0-38.4)4.8 (1.7)3.5 (3.5)
219.0 (10.5-30.9)15.2 (8.4-24.7)0.90 (0.40-2.2)0.80 (0.40)21.3 (8.4)17.7 (6.0-43.6)4.8 (1.6)3.5 (3.4)
918.2 (8.5-26.0)14.6 (8.5-26.0)1.1 (0.62-2.1)0.75 (0.41)20.9 (9.6)17.7 (6.5-51.1)4.5 (2.5)3.6 (3.4)
1011.7 (8.4-24.7)§9.3 (4.8-12.4)§2.1 (0.98-5.1)0.96 (0.60)23.5 (12.5)33 (24.1-55.0)3.9 (1.7)5.3 (2.7)
23NANANDNDND15.2 (7.2-68.3)2.9 (1.5)4.8 (3.7)
1601NANA0.93 (0.1-4.21)5.4 (9.3)29.5 (9.5)21.4 (8.8-39.9)4.6 (1.4)4.1 (3.1)
215.9 (11.1-26.8)25.4 (17.8-42.9)0.95 (0.15-3.8)0.79 (1.4)23.2 (12.3)20.4 (5.8-63.1)4.8 (1.4)3.8 (3.0)
914.2 (6.1-48.3)22.7 (9.7-77.4)0.50 (0.20-1.3)0.84 (0.80)24.3 (5.8)16.6 (7.2-34.9)4.8 (1.0)3.1 (1.9)
109.7 (7.1-22.4)15.6 (11.3-35.9)1.56 (0.90-5.8)#0.89 (0.81)25.9 (10.2)42.1 (6.8-172)#4.6 (1.0)5.8 (3.3)**
23NANANDNDND17.5 (10.5-22.0)3.5 (1.0)4.4 (1.3)
2401NANA1.0 (0.1-2.4)0.85 (0.41)22.1 (12.6)16.1 (10.5-23.3)5.8 (1.7)2.3(2.1)
213.0 (7.1-39.3)31.1 (17.0-94.3)0.95 (0.40-4.1)0.57 (0.22)15.2 (5.0)16.1 (12.2-28.3)6.0 (1.9)2.3 (2.1)
914.8 (7.4-42.6)35.5 (17.9-102.3)0.88 (0.23-5.6)0.54 (0.13)13.5 (3.0)21.9 (16.5-30.5)5.8 (1.7)3.3 (1.9)
107.5 (3.6-21.4)18.1 (8.6-51.5)3.4 (0.83-13.7)0.56 (0.3)16.4 (12.4)33.4 (19.3-73.0)5.2 (1.6)2.3 (1.7)
23NANANDNDND14.7 (10-33.3)3.7 (1.5)3.8 (2.5)
  • BW, body weight; NA, not applicable; ND, not determined; PF, plasma ferritin; PHep, plasma hepcidin; STfR, soluble transferrin receptor.

  • Doses are given on days 2, 9, and 10 at 08:00 am immediately after iron status assessment; for 40, 80 and 240 mg: n = 6; for 160 mg: n = 7.

  • * Geometric means (range).

  • Means (SD).

  • Different from day 7 and day 2 (P < .05).

  • § Different from day 7 and day 2 (P < .01).

  • Different from day 2 (P = .08).

  • Different from day 7 and day 2 (P < .001).

  • # Different to all other time points (P < .05).

  • ** Different from day 2 (P < .05).