Table 2.

Daratumumab serum concentrations with single vs split first dose in the all treated population

Postfirst doseC3 D1 preinfusionC3 D1 end of infusion
C1 D1 end of infusionC1 D2 end of infusion
Single first dose
 Patients, n899
 Mean daratumumab serum concentration, μg/mL (SD)321.14 (49.0)517.46 (137.2)895.61 (169.5)
 CV, %15.326.518.9
 Geometric mean daratumumab serum concentration, μg/mL317.73502.54882.53
Split first dose
 Patients, n695252
 Mean daratumumab serum concentration, μg/mL (SD)255.03 (71.87)618.53 (256.2)951.44 (350.1)
 CV, %28.241.436.8
 Geometric mean daratumumab serum concentration, μg/mL244.90549.57855.74
  • C, cycle; CV, coefficient of variation; D, day; SD, standard deviation.