Table 2.

Change in hemolysis measures from baseline to day 28

Change from baseline to day 28Multiple dose for 28 d
Voxelotor/placebo, mg/dPlacebo5007001000
N1010126
Hb, median (25th, 75th percentile), g/dL−0.1 (−0.4, 0.4)0.4 (0.1, 0.7)0.7 (0.5, 1.0)0 (−0.4, 0.3)
Unconjugated bilirubin, median (25th, 75th percentile), % change−3.6 (−25.9, 6.7)−30.6 (−48.9, −15.4)−42.6 (−44.4, −23.8)−56.3 (−57.8, −47.1)
Percentage of reticulocytes, median (25th, 75th percentile), % change9.0 (−1.7, 13.7)−31.2 (−48.9, −20.8)−37.0 (−52.6, −4.5)−49.9 (−64.3, −34.4)
LDH, median (25th, 75th percentile), % change−6.6 (−16.8, −2.9)−19.9 (−39.0, 6.2)−12.0 (−30.2, −5.7)−12.4 (−20.2, −12.1)
Sickled red cells, median (25th, 75th percentile), % change12.9 (−13.6, 12.9)−56.4 (−70.2, −26.2)−45.9 (−93.0, −6.0)−45.7 (−57.9, 5.9)