Table 2.

Treatment-emergent adverse events of any grade occurring in more than 25% of patients

Adverse event (N = 145)Venetoclax 400 mg (n = 60)Venetoclax 800 mg (n = 74)Venetoclax 1200 mg (n = 11)Total (N = 145)
DEC (n = 31)AZA (n = 29)DEC (n = 37)AZA (n = 37)DEC (n = 5)AZA (n = 6)
Any gradeGr3/4Any gradeGr3/4Any gradeGr3/4Any gradeGr3/4Any gradeGr3/4Any gradeGr3/4Any gradeGr3/4
Any event, n (%)31 (100)24 (77)29 (100)25 (86)37 (100)34 (92)37 (100)30 (81)5 (100)4 (80)6 (100)5 (83)145 (100)122 (84)
Nausea17 (55)018 (62)1 (3)23 (62)1 (3)23 (62)04 (80)03 (50)088 (61)2 (1)
Diarrhea13 (42)2 (6)15 (52)1 (3)22 (60)2 (5)18 (49)2 (5)4 (80)04 (67)076 (52)7 (5)
Constipation14 (45)017 (59)2 (7)15 (41)018 (49)02 (40)04 (67)070 (48)2 (1)
Febrile neutropenia19 (61)19 (61)11 (38)11 (38)15 (41)15 (41)13 (35)13 (35)2 (40)2 (40)3 (50)3 (50)63 (43)63 (43)
Fatigue12 (39)3 (10)10 (34)013 (35)3 (8)13 (35)1 (3)4 (80)1 (20)2 (33)054 (37)8 (6)
Hypokalemia10 (32)4 (13)5 (17)2 (7)17 (46)5 (14)11 (30)3 (8)3 (60)1 (20)3 (50)049 (34)15 (10)
Decreased appetite8 (26)08 (28)1 (3)13 (35)1 (3)14 (38)1 (3)3 (60)02 (33)048 (33)3 (2)
Decreased WBC count13 (42)13 (42)7 (24)7 (24)10 (27)10 (27)12 (32)12 (32)2 (40)2 (40)1 (17)1 (17)45 (31)45 (31)
Vomiting10 (32)09 (31)010 (27)010 (27)03 (60)02 (33)044 (30)0
Anemia7 (23)7 (23)9 (31)9 (31)11 (30)10 (27)11 (30)9 (24)2 (40)1 (20)0040 (28)36 (25)
Cough10 (32)06 (21)011 (30)010 (27)02 (40)02 (33)041 (28)0
Peripheral edema7 (23)010 (34)012 (32)010 (27)01 (20)01 (17)041 (28)0