Table 1.

Proposed unifying nomenclature and examples of immunodeficiency-associated LPDs

3-Part unifying nomenclature
Name of lesionViral statusSpecific immunodeficiency setting
B-cell hyperplasia (eg, plasmacytic hyperplasia)eg, EBV+/−, HHV8+/−eg, Posttransplant (solid organ), iatrogenic (methotrexate), immune senescence
Polymorphic B-cell lymphoproliferations (eg, mucocutaneous ulcer)
Lymphoma (WHO terminology) (eg, diffuse large B-cell lymphoma, Anaplastic large cell lymphoma, ALK)
Examples of diagnostic labels
Proposed unifying nomenclatureWHO 2016 nomenclature
Plasmacytic hyperplasia, EBV+, posttransplant (solid organ)Plasmacytic hyperplasia, nondestructive posttransplant LPD
Polymorphic B-LPD, EBV+, iatrogenic (methotrexate)Polymorphic LPD resembling polymorphic posttransplant LPD
Mucocutaneous ulcer, EBV+, primary immunodeficiency (CHARGE syndrome)EBV+ mucocutaneous ulcer
Diffuse large B-cell lymphoma, EBV, HIV infectionDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma, T-cell/histiocyte-rich, EBV+, immune senescenceEBV+ diffuse large B-cell lymphoma
Primary effusion lymphoma, HHV8+, EBV+, HIV infectionPrimary effusion lymphoma