Table 1.

Response criteria

ResponseCriteria
cCRPatients achieving criteria for either CR or CRi:
CR: M1 marrow,* absence of peripheral blasts (morphologic), absence of extramedullary sites of disease, peripheral blood neutrophil count ≥1000/μL, and platelet count ≥100 000/μL
CRi: above CR criteria without specified blood counts
PRM2 marrow* and decrease in percentage of marrow blasts by ≥50%, absence of peripheral blasts (morphologic), absence of extramedullary sites of disease
Hematologic activityDoes not meet criteria for CR or PR, with any of the following:
≥50% decrease in percentage of marrow blasts
≥50% decrease in absolute peripheral blast count
Improvement of peripheral blood neutrophil count to ≥1000/μL or platelet count to ≥100 000/μL
Stable diseaseDoes not meet criteria for CR, PR, HA, or PD
Progressive disease or relapseDeterioration in marrow classification (ie, M status*) with ≥50% increase in percentage of marrow blasts compared with best response OR
No change in marrow classification (ie, M status*) but ≥50% increase in absolute peripheral blast count or extent of extramedullary disease compared with best response
  • cCR, composite CR; CRi, CR with incomplete blood count recovery; HA, hematologic activity; PD, progressive disease; PR, partial response.

  • * Bone marrow classification (blast percentage, ≥200 cells counted): M1, <5%; M2, 5% to 25%; M3, >25%.

  • Central nervous system classification (cerebrospinal fluid cell count and cytology): CNS1, 0 blasts on cytospin; CNS2, white cell count <5/µL and blasts on cytospin; CNS3, white cell count ≥5/µL and blasts on cytospin.