Table 3.

Univariate and multivariate analysis for OS (overall population)

VariableUnivariate analysisMultivariate analysis
HR95% CIPHR95% CIP
Age1.9480.590-6.438.274
 ≤60 y
 >60 y
WHO diagnosis1.3430.594-3.034.478
 MDS
 MDS/MPN
Cytopenias2.2301.015-4.899.0464.1970.340-51.865.264
 0-1
 ≥2
BM blasts1.3930.657-2.957.387
 <5%
 ≥5
Cytogenetic risk0.5000.213-1.170.110
 Good
 Others
Transfusion2.3041.070-4.959.0331.2420.186-8.301.823
 Dependent
 Independent
IPSS risk1.1440.398-3.293.803
 Low
 Intermediate 1
IPSS-R risk1.2630.519-3.188.406
 High or very high
 Others
MDA LR-MDS score1.2580.607-2.606.537
 High (category 3)
 Others
Response0.3780.161-0.890.0260.0450.002-0.995.047
 CR
 Non-CR
DNMT3A5.7191.621-20.181.00725.9300.904-743.842.057
 Wild-type
 Mutated
TP533.6821.228-11.035.020136.7645.292-3534.38.003
 Wild-type
 Mutated
ZRSR245.4752.843-727.310.00794.8652.528-3559.721.014
 Wild-type
 Mutated