Table 2.

Mouse studies on the role of tumor-derived TF+ MVs in cancer-associated thrombosis

Tumor typeMouseTumor siteConclusionReference
Human colorectal cancer cell linesSCIDSubcutaneousHuman TF antigen in plasma83
Human pancreatic cancer cell line L3.6plNudeOrthotopicHuman TF MV activity and TAT in plasma84
Mouse pancreatic cancer cell line Panc02 and lung cancer cell line LLC1C57BL/6JSubcutaneousIncreased thrombosis in mesenteric ferric chloride model57
Human pancreatic cancer cell lines HPAF-II and HPACNudeSubcutaneous and orthotopicHuman TF antigen and MV activity and TAT in plasma67
Mouse pancreatic cancer cell line Panc02C57BL/6JSubcutaneousIncreased thrombosis in IVC stenosis model85
Human pancreatic cancer cell lines BxPc-3 and L3.6plNudeOrthotopicIncreased thrombosis in IVC stenosis model54
Human pancreatic cancer cell line BxPc-3NudeOrthotopicHuman TF+ MVs increase thrombosis in IVC stasis model30
  • TAT, thrombin-antithrombin [complex].