Table 3.

Correlation between biomarkers and clinical outcomes

BiomarkerP valueHazard ratioHR lower CLHR upper CL
Nonrelapse mortality by 2 y*
 ST2.000382.431.493.95
 IL-6.00903.801.3910.33
 Reg3α.000732.351.433.87
 TIM3<.00014.872.539.34
Overall survival
 ST2.00141.731.242.41
 IL-6.00222.421.374.25
 Reg3α<.00012.001.462.73
 TIM3.000351.871.332.65
Chronic GVHD§
 ST2.301.130.891.44
 CXCL9.00691.601.142.26
 OPN.060.730.521.01
 MMP3.900.990.851.16
  • * Proportional hazards model with time-dependent covariates adjusting for treatment group, age, and CMV status.

  • High vs low (see Patients and methods).

  • Proportional hazards model with time-dependent covariates adjusting for treatment regimen.

  • § Proportional hazards model with time-dependent covariates adjusting for treatment group and primary malignancy.