Table 3.

Pharmacological features of factor XII– or factor XI–directed strategies

FeatureAntisense oligonucleotidesAntibodiesAptamersSmall molecules
DeliveryParenteralParenteralParenteralParenteral or oral
SpecificYesYesYesYes
Onset of actionDelayedImmediateImmediateImmediate
Offset of actionDelayedDelayedRapidRapid
Renal clearanceNoNoNoVariable
Hepatic metabolismNoNoNoVariable
Potential clinical indicationsChronicAcute or chronicAcute or chronicAcute or chronic