Table 1.

Sickle cell guidelines and recommendations with relevance for sub-Saharan Africa

TopicGoalAge rangeApplicable to AfricaFeasible for AfricaNeed for more testingCurrent trials
ScreeningDiagnosis
 Electrophoresis by IEF, HPLC, CZENeonates, teens, young adultsYesYesNoNo
 Point-of-care testingNeonates, teens, young adultsYesYesYesYes
EducationEarly recognition
 Splenic sequestration<2 yYesYesNoNo
 Fever managementAll agesYesYesNoNo
Preventive careProphylaxis
 AntimalarialsAll agesYesYesYesYes
 Insecticide-treated bed netsAll AgesYesYesNoNo
 Penicillin<5 yYesYesNoNo
 Vaccination<5 yYesYesNoNo
 Antibiotics for feverAll agesYesYesNoNo
 Blood culture with feverAll agesYesNoNoNo
ScreeningEarly identification
 TCD ultrasound2-16 yYesYesYesYes
 ProteinuriaAll agesYesYesYesYes
 Cardiac function (TR Jet velocity)AdultsPossiblyPossiblyYesNo
TreatmentTherapeutic
 TransfusionsAll agesYesYesYesNo
 HydroxyureaAll agesYesYesYesYes
 TransplantationAll agesNoNoNoNo