Table 2.

Regulated GAP and GEF proteins belonging to the Rho/Rac pathway

GDP exchange proteins (GEF)GTPase-activating proteins (GAP)
AccessionGeneSiteRegulationAccessionGeneSiteRegulation
Q12802AKAP13Ser1750↑10ADPP98171ARHGAP4Ser860↑10ADP
Ser2709↑10ADP
Q92974ARHGEF2Ser121/122↑10ADPO43182ARHGAP6Ser927↑10ADP
Ser820/Thr821↓60ADP
Q14155ARHGEF7Ser674/676↑30ADPQ53QZ3ARHGAP15Ser43↑30ADP
O15013ARHGEF10Ser379↑10ADPA7KAX9ARHGAP32Ser587↑60ADP
Q9NZN5ARHGEF12Ser22↑10ADPQ92619HMHA1Ser14↑10ADP
Ser599↑10ADPSer73↑10ADP
Thr96/Ser99↑10ADP
Q9H7D0DOCK5Ser1742↑10ADPQ13576IQGAP2Ser16↑10ADP
Ser1766↑10ADP
Ser1781↑10ADP
Q96N67DOCK7Ser182↑10ADPQ13459MYO9BThr1271↑10ADP
Ser1354↓60ADP
Thr1492↑10ADP
Ser1972↑10ADP
Q5JSL3DOCK11Ser31↑10ADPO60890OPHN1Ser703↑30ADP
O60229KALRNSer1896↑10ADP
Ser2261↑10ADP
Ser1756 + 1757↑10ADP
Q07890SOS2Ser1315↑10ADP
P21731TBXA2Ser329↑30ADP
Q9UKW4VAV3Ser786↑10ADP
  • ↑10ADP corresponds to upregulation after 10 seconds of ADP stimulation. If the phosphorylated site could not be localized to a distinct Ser/Thr/Tyr residue with high confidence (eg, ARHGAP6), all possibly phosphorylated residues are listed, according to the phosphoRS algorithm.