Table 1.

Transgenic murine hematologic indices

Mean ± SD
Wild-typew/ human Hb sitew/o Hb site
n81215
(4 female; 4 male)(6 female; 6 male)(7 female; 8 male)
 RBC, ×1012/L10.67 ± 0.6410.58 ± 0.258.91 ± 1.36*
 Hb, g/L160.3 ± 2.8159.8 ± 5.1153.7 ± 6.1*
 Hematocrit, %47.34 ± 2.0444.63 ± 1.40*44.06 ± 2.46*
 MCH15.33 ± 0.3915.36 ± 0.4216.77 ± 0.80*
 MCV, fL42.18 ± 1.6942.12 ± 0.4847.68 ± 2.27*
 Reticulocytes, %4.35 ± 0.294.62 ± 0.535.14 ± 0.78
 WBC, ×109/L7.00 ± 3.367.68 ± 0.93*11.86 ± 3.46*
 Platelet, ×109/L899.8 ± 110850.0 ± 104805.4 ± 111
n545
 Total cells in marrow, ×1077.30 ± 0.628.38 ± 1.847.78 ± 1.65
 Ter119+ cells in marrow, ×1072.87 ± 0.393.43 ± 1.153.63 ± 1.07
 Ter119+ cells in marrow (%)39.3 ± 4.240.8 ± 10.546.6 ± 8.1*
 Total cells in spleen, ×10730.14 ± 5.8134.35 ± 7.3760.61 ± 9.38*
 Ter119+ cells in spleen, ×10714.88 ± 2.8319.98 ± 5.5550.49 ± 12.95*
 Ter119+ cells in spleen, %49.9 ± 3.157.8 ± 6.4*82.4 ± 12.4*
 Spleen weight, g0.11 ± 0.010.13 ± 0.040.24 ± 0.04*
  • SD, standard deviation; w/, with; w/o, without.

  • * P < .05 compared with the wild-type (C57BL/6) strain.

  • P < .05 compared with the transgenic strain with the human Hb site.