Table 1.

IRC for solid tumors

Response designationDefinition
ir complete remissionComplete disappearance of all lesions (whether measureable or not, and no new lesions), confirmed by a repeat, consecutive assessment no less than 4 weeks from the date first documented
ir partial remissionDecrease in tumor burden ≥50% relative to baseline confirmed by a consecutive assessment at least 4 weeks after first documentation
ir stable diseaseNot meeting criteria for irCR or irPR, in absence of irPD
ir progressive diseaseIncrease in tumor burden ≥25% relative to nadir (minimum recorded tumor burden), confirmed by a repeat, consecutive assessment no less than 4 weeks from the date first documented
  • Adapted from Wolchok et al.31 ir, immune response.