Table 5

PK parameters following a 30-minute IV infusion of carfilzomib

Parameter*Dose
20 mg/m2 (n = 25)70 mg/m2 (n = 21)88 mg/m2 (n = 5)
t1/2, h0.64 (0.193-1.29)0.950 (0.572-1.29)0.848 (0.648-0.952)
Cmax, ng/mL724 (42.9)2390 (30.7)3090 (27.3)
AUC0-last, ng × h/mL260 (27.6)1030 (20.5)1190 (29.1)
AUCinf, ng × h/mL260 (27.6)1030 (21.2)§1140 (31.5)
CL, L/h146 (30.4)131 (28.6)§138 (34.3)
  • AUC0-last, AUC from time 0 to last time measurable concentration; AUCinf, AUC from time 0 to infinity; CL, clearance; t1/2, terminal half-life.

  • * Except for t1/2, which is expressed as median (minimum to maximum), all other parameters are shown as geometric mean (% coefficient of variation).

  • n = 16.

  • n = 4.

  • § n = 17.