Parameter^{*} | Dose | ||
---|---|---|---|

20 mg/m^{2} (n = 25) | 70 mg/m^{2} (n = 21) | 88 mg/m^{2} (n = 5) | |

t_{1/2}, h | 0.64 (0.193-1.29) | 0.950 (0.572-1.29)^{†} | 0.848 (0.648-0.952)^{‡} |

C_{max}, ng/mL | 724 (42.9) | 2390 (30.7) | 3090 (27.3) |

AUC_{0-last}, ng × h/mL | 260 (27.6) | 1030 (20.5) | 1190 (29.1) |

AUC_{inf}, ng × h/mL | 260 (27.6) | 1030 (21.2)^{§} | 1140 (31.5)^{‡} |

CL, L/h | 146 (30.4) | 131 (28.6)^{§} | 138 (34.3)^{‡} |

AUC

_{0-last}, AUC from time 0 to last time measurable concentration; AUC_{inf}, AUC from time 0 to infinity; CL, clearance; t_{1/2}, terminal half-life.↵* Except for t

_{1/2}, which is expressed as median (minimum to maximum), all other parameters are shown as geometric mean (% coefficient of variation).↵† n = 16.

↵‡ n = 4.

↵§ n = 17.