Table 4

Best overall response

Phase 1Phase 2Phase 1-2
45 mg/m2 (n = 3)56 mg/m2 (n = 3)70 mg/m2 (n = 15)88 mg/m2 (n = 6)70 mg/m2 (n = 89)70 mg/m2 (n = 104)
Stringent CR, n (%)01 (33)1 (7)1 (17)2 (2)3 (3)
CR, n (%)02 (67)4 (27)1 (17)7 (8)11 (11)
Very good PR, n (%)003 (20)031 (35)34 (33)
PR, n (%)1 (33)06 (40)2 (33)26 (29)32 (31)
Minimal response, n (%)1 (33)01 (7)1 (17)6 (7)7 (7)
Stable disease, n (%)1 (33)00012 (13)12 (12)
Progressive disease, n (%)00002 (2)2 (2)
Not evaluable, n (%)0001 (17)3 (3)3 (3)
ORR, % (95% CI)3310093677477 (68-85)
CBR, % (95% CI)67100100838184 (75-90)