Table 10

Molecular genetic abnormalities in myeloid/lymphoid neoplasms associated with eosinophilia

DiseasePresentationGeneticsTreatment
PDGFRAEosinophiliaCryptic deletion at 4q12Respond to TKI
↑Serum tryptaseFIP1L1-PDGFRA, at least 66 other partners
↑Marrow mast cells
PDGFRBEosinophiliat(5;12)(q32;p13.2) ETV6-PDGFRB, at least 25 other partnersRespond to TKI
Monocytosis mimicking CMML
FGFR1EosinophiliaTranslocations of 8p11.2Poor prognosis; do not respond to TKI
Often presents with T-ALL or AMLFGFR1-various partners
PCM1-JAK2Eosinophiliat(8;9)(p22;p24.1) PCM1-JAK2May respond to JAK2 inhibitors
Rarely presents with T-LBL or B-ALL
Bone marrow shows left-shifted erythroid predominance and lymphoid aggregates
  • ↑, Increased.