Table 1

2016 WHO classification of mature lymphoid, histiocytic, and dendritic neoplasms

Mature B-cell neoplasms
 Chronic lymphocytic leukemia/small lymphocytic lymphoma
 Monoclonal B-cell lymphocytosis*
 B-cell prolymphocytic leukemia
 Splenic marginal zone lymphoma
 Hairy cell leukemia
Splenic B-cell lymphoma/leukemia, unclassifiable
  Splenic diffuse red pulp small B-cell lymphoma
  Hairy cell leukemia-variant
 Lymphoplasmacytic lymphoma
  Waldenström macroglobulinemia
 Monoclonal gammopathy of undetermined significance (MGUS), IgM*
 μ heavy-chain disease
 γ heavy-chain disease
 α heavy-chain disease
 Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
 Plasma cell myeloma
 Solitary plasmacytoma of bone
 Extraosseous plasmacytoma
 Monoclonal immunoglobulin deposition diseases*
 Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
 Nodal marginal zone lymphoma
  Pediatric nodal marginal zone lymphoma
 Follicular lymphoma
  In situ follicular neoplasia*
  Duodenal-type follicular lymphoma*
 Pediatric-type follicular lymphoma*
Large B-cell lymphoma with IRF4 rearrangement*
 Primary cutaneous follicle center lymphoma
 Mantle cell lymphoma
  In situ mantle cell neoplasia*
 Diffuse large B-cell lymphoma (DLBCL), NOS
  Germinal center B-cell type*
  Activated B-cell type*
 T-cell/histiocyte-rich large B-cell lymphoma
 Primary DLBCL of the central nervous system (CNS)
 Primary cutaneous DLBCL, leg type
 EBV+ DLBCL, NOS*
EBV+ mucocutaneous ulcer*
 DLBCL associated with chronic inflammation
 Lymphomatoid granulomatosis
 Primary mediastinal (thymic) large B-cell lymphoma
 Intravascular large B-cell lymphoma
 ALK+ large B-cell lymphoma
 Plasmablastic lymphoma
 Primary effusion lymphoma
HHV8+ DLBCL, NOS*
 Burkitt lymphoma
Burkitt-like lymphoma with 11q aberration*
 High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
 High-grade B-cell lymphoma, NOS*
 B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
Mature T and NK neoplasms
 T-cell prolymphocytic leukemia
 T-cell large granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK cells
 Aggressive NK-cell leukemia
 Systemic EBV+ T-cell lymphoma of childhood*
 Hydroa vacciniforme–like lymphoproliferative disorder*
 Adult T-cell leukemia/lymphoma
 Extranodal NK-/T-cell lymphoma, nasal type
 Enteropathy-associated T-cell lymphoma
 Monomorphic epitheliotropic intestinal T-cell lymphoma*
Indolent T-cell lymphoproliferative disorder of the GI tract*
 Hepatosplenic T-cell lymphoma
 Subcutaneous panniculitis-like T-cell lymphoma
 Mycosis fungoides
 Sézary syndrome
 Primary cutaneous CD30+ T-cell lymphoproliferative disorders
  Lymphomatoid papulosis
  Primary cutaneous anaplastic large cell lymphoma
 Primary cutaneous γδ T-cell lymphoma
Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
Primary cutaneous acral CD8+ T-cell lymphoma*
Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
 Peripheral T-cell lymphoma, NOS
 Angioimmunoblastic T-cell lymphoma
Follicular T-cell lymphoma*
Nodal peripheral T-cell lymphoma with TFH phenotype*
 Anaplastic large-cell lymphoma, ALK+
 Anaplastic large-cell lymphoma, ALK*
Breast implant–associated anaplastic large-cell lymphoma*
Hodgkin lymphoma
 Nodular lymphocyte predominant Hodgkin lymphoma
 Classical Hodgkin lymphoma
  Nodular sclerosis classical Hodgkin lymphoma
  Lymphocyte-rich classical Hodgkin lymphoma
  Mixed cellularity classical Hodgkin lymphoma
  Lymphocyte-depleted classical Hodgkin lymphoma
Posttransplant lymphoproliferative disorders (PTLD)
 Plasmacytic hyperplasia PTLD
 Infectious mononucleosis PTLD
 Florid follicular hyperplasia PTLD*
 Polymorphic PTLD
 Monomorphic PTLD (B- and T-/NK-cell types)
 Classical Hodgkin lymphoma PTLD
Histiocytic and dendritic cell neoplasms
 Histiocytic sarcoma
 Langerhans cell histiocytosis
 Langerhans cell sarcoma
 Indeterminate dendritic cell tumor
 Interdigitating dendritic cell sarcoma
 Follicular dendritic cell sarcoma
 Fibroblastic reticular cell tumor
 Disseminated juvenile xanthogranuloma
 Erdheim-Chester disease*
  • Provisional entities are listed in italics.

  • * Changes from the 2008 classification.