Table 4

Clinical outcomes according to age at diagnosis of HCL

≤40 y of age (n = 88)All patients (n = 209)6
Median age (range)36 y (20-40)50 y (28-79)
Response rate100%100%
Complete88%95%
Partial12%5%
Median response duration (mo)57 (range, 7-246 mo)98 (range, 8-172 mo)
Relapse rate58%37%
Median time to relapse (mo)54 (range, 7-246 mo)42 (range, 8-118 mo)
Observed-to-expected ratio of developing a second malignancy1.60 (95% CI, 0.80-2.89)2.03 (95% CI, 1.49-2.71)
  • CI, confidence interval.