Table 1

Young HCL patient demographics at first treatment of cladribine

No. of patients88
Male/female63/25 (72%/28%)
Age, y
 Median36 y
 Range20-40 y
Prior therapy
 Splenectomy alone7
 Interferon alone17
 Splenectomy, interferon15
 Splenectomy, interferon, 2′-deoxycoformycin2
 Chlorambucil, splenectomy1
 Chlorambucil, interferon, splenectomy3
 Other regimens1
Duration from diagnosis of HCL to the first cladribine course
 Median16 mo
 Range2 d to 470 mo
Peripheral blood hematologic parameters
 Absolute neutrophil count (×109/L)
  Median (range)0.6 (0.1-2.7)
 White blood cell count (×109/L)
  Median (range)2.8 (0.3-30.3)
 Hemoglobin level (g/dL)
  Median (range)10.7 (3.2-16.1)
 Platelets (×109/L)
  Median (range)63 (11-136)